Ćwikły-Rupie [ˈt͡ɕfikwɨ ˈrupjɛ] is a village in the administrative district of Gmina Kołaki Kościelne, within Zambrów County, Podlaskie Voivodeship, in north-eastern Poland. It lies approximately 6 kilometres (4 mi) north-east of Zambrów and 58 km (36 mi) west of the regional capital Białystok.