Średnie Duże [ˈɕrɛdɲɛ ˈduʐɛ] is a village in the administrative district of Gmina Nielisz, within Zamość County, Lublin Voivodeship, in eastern Poland. It lies approximately 23 kilometres (14 mi) north-west of Zamość and 55 km (34 mi) south-east of the regional capital Lublin.