161 Sussex Street is a heritage-listed historic site located at 161 Sussex Street, in the Sydney central business district, in the City of Sydney local government area of New South Wales, Australia. The property is owned by Property NSW, an agency of the Government of New South Wales. It was added to the New South Wales State Heritage Register on 2 April 1999.

As of 2016 the heritage listed hotel forecourt that was previously located at 161 Sussex Street was demolished and made way for the Hyatt Regency Sydney/Four Point development. All that remains is a heritage marker on the driveway in the hotel forecourt.

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The current site forms part of the Hyatt Regency Sydney/Four Points by Sheraton Hotel development. Redeveloped in 2016 by COX Architecture, the heritage-listed site was conserved and a nearby adjacent 26-storey tower was constructed that added 222 new guest rooms, 3,667 square metres (39,470 sq ft) convention centre, and commercial office space. The additions were completed in the Millennium Minimalist Modernism style.

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161 Sussex Street was listed on the New South Wales State Heritage Register on 2 April 1999.

• Hyatt

This Wikipedia article was originally based on Building, entry number 414 in the New South Wales State Heritage Register published by the State of New South Wales (Department of Planning and Environment) 2018 under CC-BY 4.0 licence, accessed on 13 October 2018.

• "161 Sussex Street redevelopment". COX Architecture. n.d.
• "Assessment Report: Four Points by Sheraton Hotel Redevelopment: 161 Sussex Street, Sydney" (PDF). NSW Planning & Infrastructure. Government of New South Wales. June 2013. pp. 36–39.