The 1949 U.S. Women's Open was the fourth U.S. Women's Open, held September 22–25 at Prince George's Country Club in Landover, Maryland, a suburb east of Washington, D.C.

Louise Suggs led wire-to-wire and won the first of her two U.S. Women's Open titles, fourteen strokes ahead of runner-up Babe Zaharias, the defending champion. It was the fourth of eleven major championships for Suggs.

The course no longer exists and is now the site of Kentland Community Center Park.

Final leaderboard

Sunday, September 25, 1949

Place	Player	Score	To par	Money ($)
1	Louise Suggs	69-75-77-70=291	−9	1,500
2	Babe Zaharias	74-76-75-80=305	+5	1,000
3	Carol Diringer (a)	75-76-77-78=306	+6	0
T4	Patty Berg	73-84-78-75=310	+10	800
	Dot Kielty (a)	74-83-76-77=310		0
T6	Marlene Bauer (a)	75-78-78-80=311	+11	0
	Beverly Hanson (a)	72-81-75-83=311
	Mae-Murray Jones (a)	78-78-79-76=311
	Frances Stephens (a)	75-81-80-75=311
10	Polly Riley (a)	75-83-79-75=312	+12	0