The 1978 LPGA Championship was the 24th LPGA Championship, held June 8–11 at Jack Nicklaus Golf Center at Kings Island in Mason, Ohio, a suburb northeast of Cincinnati.

Nancy Lopez, a 21-year-old tour rookie, won the first of her three major titles, all at the LPGA Championship at Kings Island. She finished at 275 (−13), six strokes ahead of runner-up Amy Alcott.

It was the sixth tour win for Lopez and her fourth consecutive in 1978, and she won the following week to run the streak to five.

This was the first of twelve consecutive LPGA Championships at Kings Island; the last one in 1989 was also won by Lopez.

Final leaderboard

Sunday, June 11, 1978

Place	Player	Score	To par	Money ($)
1	Nancy Lopez	71-65-69-70=275	−13	22,500
2	Amy Alcott	68-68-74-71=281	−7	14,650
3	Judy Rankin	67-73-71-72=283	−5	10,510
4	JoAnne Carner	71-72-70-71=284	−4	7,700
5	Jo Ann Washam	67-69-74-75=285	−3	6,080
T6	Donna Caponi Young	73-72-71-70=286	−2	4,813
	Susan Lynn Grams	73-73-71-69=286
	Sally Little	73-71-74-68=286
T9	Jane Blalock	72-73-73-69=287	−1	3,750
	Dot Germain	73-69-75-70=287
	Hollis Stacy	69-75-72-71=287

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