On January 5, 2002, Charles J. Bishop, a high-school student of East Lake High School in Tarpon Springs, Florida, United States, stole a Cessna 172 light aircraft and crashed it into the side of the Bank of America Tower in downtown Tampa, Florida. The impact killed the teenager and damaged an office room, but there were no other injuries.

Bishop had been inspired by the September 11 attacks; he had left a suicide note crediting Osama bin Laden for the attacks and praising it as a justified response to actions against the Palestinians and Iraqis and said he (Bishop) was acting on behalf of Al Qaeda, from whom he had turned down help. As officials could find no other evidence of any connections, terrorism as a motive was ruled out, and they suggested that the crash was an apparent suicide. Bishop's mother filed, then dropped, a lawsuit claiming that psychological side effects from isotretinoin caused the incident. Bishop used isotretinoin, which is known to induce depression and rarely suicidal actions, as an acne medicine.

At 5:00 p.m. EST, 15-year-old Charles J. Bishop's flight instructor left him at the plane to perform basic preflight inspection. Once he was left alone inside the plane, he started the engine and took off without permission. As soon as the plane took off, the air traffic controllers alerted the United States Coast Guard and MacDill Air Force Base. Despite repeated warnings from a helicopter dispatched by the Coast Guard, the Cessna continued on in flight until it crashed into the Bank of America tower. The plane crashed between the 28th and 29th floors of the 42-story building.

An investigation followed the incident. Officials ruled out terrorism although eyewitnesses said that the plane made no apparent attempt to avoid hitting the building. Officials finally suggested that the crash was an apparent suicide. In addition, a note found in the wreckage stated that he voiced support for Osama bin Laden. However, there is no evidence that the teen had any connection with any terror group. A suicide note from Bishop was found stating:

I have prepared this statement in regards to the acts I am about to commit. First of all, Osama bin Laden is absolutely justified in the terror he has caused on 9-11. He has brought a mighty nation to its knees! God blesses him and the others who helped make September 11th happen. The U.S. will have to face the consequences for its horrific actions against the Palestinian people and Iraqis by its allegiance with the monstrous Israelis—who want nothing short of world domination! You will pay—God help you—and I will make you pay! There will be more coming! Al Qaeda and other organizations have met with me several times to discuss the option of me joining. I didn't. This is an operation done by me only. I had no other help, although, I am acting on their behalf.

Later authorities confiscated a computer from Bishop's parents' house to try to determine a motive for the incident. Moments after the incident, President George W. Bush was briefly informed about the incident and two unrelated crashes that same day.

In April 2002, transcripts obtained from the Federal Aviation Administration revealed new details about the incident, which included how close the small plane came to a Southwest Airlines flight.

Bishop's mother filed a $70 million (2002 USD) lawsuit against Roche Laboratories, who make an acne medicine called Accutane. According to the lawsuit claim, the medicine had side effects such as depression and suicidal actions, which the claim stated as the cause of the incident. The suit was dropped on June 26, 2007, by Bishop's mother, who stated she was physically and emotionally unable to continue the action.

After the incident took place, numerous security measures were taken. The FAA released a security notice on January 6, the day after the incident. The notice included security of the aircraft and regulations pertaining to underaged flight students. In addition, the Experimental Aircraft Association and other smaller aircraft organizations proposed more security of flight schools and small aircraft.

While authorities stated that the crash was due to an "abuse of trust" rather than a security breach, others argue for the need of increased security due to the simplicity of such actions.

• 1945 Empire State Building B-25 crash – Aviation accident
• 2002 Pirelli Tower airplane crash – Airplane crash in Milan, Italy
• 2006 New York City Cirrus SR20 crash – Aircraft crash into a building
• 2010 Austin suicide attack – Suicide by pilot in Austin, Texas
• 2014 Wichita King Air crash – Aviation disaster in Kansas, US
• 2018 Horizon Air Q400 incident – Aircraft crash in United States, August 2018
• List of terrorist incidents in 2002

• NTSB report