The A5 Autoroute, which was constructed in 1990 to relieve the A6, links the Parisian region with the Langres area. It is a 238 km toll road under the management of the Autoroutes Paris-Rhin-Rhône (APRR). It makes up parts of the European routes E54, E511, and E17. Before the A5 was completed, the section linking Troyes with Langres was known as the A26. This route crosses the departments of Seine-et-Marne (in the Ile-de-France region), Yonne (in the Burgundy region), Aube and Haute-Marne (in the Champagne-Ardenne region).

In Île-de-France, before reaching its western terminus at La Francilienne, the A5 splits into two branches which were previously referred to as the A5a and the A5b. They have since been renumbered, with the A5a being designated as the A5 and the A5b becoming part of the A105 (a spur route linking La Francilienne, the A5, and the town of Melun). However, the two branches are often still referred to as the "A5a" and "A5b".

The French Government has given the green light for the completion of the natural continuation of the A5 beyond Langres towards Switzerland and Mulhouse by granting permission for the construction of a toll motorway from Langres to Vesoul currently known as the A319 (planned opening after 2030). The remainder of the section must be supported by the State in the form of a 2 × 2 lane expressway (RN 19) connecting to the A36 between Belfort and Montbéliard and beyond to the A16 Swiss motorway. The combination of the current A5 motorway and this extension could eventually become a future A5 motorway linking Paris to Switzerland.

This article contains a bulleted list or table of intersections which should be presented in a properly formatted junction table. Please consult this guideline for information on how to create one. Please improve this article if you can. (December 2021)

Exit/Junction	Destination
	La Francilienne/ N 104 N 6
10a	Savigny-le-Temple
10b	Savigny-Plessis, Lieusaint, Moissy-Cramayel
10c	Lieusaint, Moissy-Cramayel
11  Eastbound only	Savigny-centre
12  Eastbound only	Savigny - Parc d'Activites
Aire du Plessis-Picard-Les Poiriers (eastbound)  Aire du Plessis-Picard-Ourdy (westbound)
13  Westbound only	Cesson-Vert St Denis
	A 105 A 5b Marne la Valee, Melun
Aire des Éprunes (westbound)
Péage des Eprunes
Aire des Éprunes (eastbound)
15	Saint-Germain-Laxis
16	Châtillon-la-Borde
Aire des Jonchets-La Grande Paroisee (eastbound)  Aire des Jonchets-Les Récompenses (westbound)
17	Forges
18	Marolles-sur-Seine
Aire des Rasets (eastbound)  Aire de Gravon (westbound)
Border between Seine-et-Marne (Ile-de-France) and Yonne (Burgundy)
	A 19 Sens, Provins, Orléans
Aire de Montand (eastbound)  Aire de Montaphilant (westbound)
Aire de Villeneuve-l'Archevêque (eastbound)  Aire de Villeneuve-Vauluisant (westbound)
19	Villeneuve-l'Archevêque, Nogent sur Seine, St. Florentin
Border between Yonne (Burgundy) and Aube (Champagne-Ardenne)
Aire des Tomelles (eastbound)  Aire des Fontvannes (westbound)
20	Troyes-Centre, Sainte-Savine
Aire de Saint-Pouange (eastbound)  Aire de la Coloterie (westbound)
21	Troyes-Sud, Saint-Julien-les-Villas, Tonnerre
	A 26 Lille, Reims
Aire de Troyes-Fresnoy-le-Château (eastbound)  Troyes-Le-Plessis (westbound)
22	Châtillon, Brienne, Bar sur Aube
Aire de Mondeville (eastbound)  Aire de Champignol (westbound)
23	Chateauvillain, Châtillon, Bar sur Aube
Border between Aube and Haute-Marne
Aire de Châteauvillain-Val-Marnay (eastbound)  Aire de Châteauvillain-Orges (westbound)
24	Chaumont, Semoutiers, St. Dizier
Aire de Bois-Moyen (eastbound)  Aire de Champs-à-la-Croix (westbound)
	A 31Lyon-Dijon Metz-Nancy

Exit/Junction	Destination
	La Francilienne/ N 104
11	Évry-Grégy-sur-Yerre
12	Moissy-Cramayel, Guignes
13	Réau
Aire de Galande-la-Sablière (southbound)  Aire de Galande-La-Mare-Laroche (northbound)
	A 5
14	Cesson, Vert-Saint-Denis, Voisenon

European Route	Location
E54	entire length
E511	A 19 through   A 26
E17	A 26 through   A 31

European Route	Location
E54	entire length

• Autoroute A5 on Saratlas