State Route 143 (SR 143) is a 28.598-mile-long (46.024 km) north–south state highway in the central part of the U.S. state of Alabama, extending north from Interstate 65 (I-65) and U.S. Route 82 (US 82) northwest of Montgomery to US 31 near Clanton. It parallels I-65, traveling through Millbrook, Elmore, and Deatsville.

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Prior to the 1957 renumbering, SR 143 was numbered State Route 45; it was renumbered because of US 45.

Prior to the construction of I-65, SR 143 crossed the Alabama River on the Tyler–Goodwyn Bridge and entered Montgomery on Parallel Street. The bridge, scene of the murder of Willie Edwards, was subsequently removed.

County	Location	mi	km	Destinations	Notes
Montgomery	​	0.000	0.000	I-65 south / US 82 east (SR 6)	Southern terminus; no access from I-65 south/US 82 east or to I-65 north/US 82 west
Elmore	Millbrook	4.181	6.729	To I-65 north (Cobbs Ford Road)
		7.131	11.476	SR 14 west to I-65 – Prattville	South end of SR 14 concurrency
	​	11.372	18.301	SR 14 east – Wetumpka	North end of SR 14 concurrency
Autauga	​	22.451	36.131	SR 111 east / CR 121 west	Western terminus of SR 111; eastern terminus of CR 121
Chilton	​	28.598	46.024	US 31 (SR 3) – Prattville, Clanton	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Incomplete access

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