State Route 64 (SR 64) is an 18.230-mile-long (29.338 km) east–west state highway entirely within Lauderdale County in the northwest portion of the U.S. state of Alabama. The western terminus of the highway is at an intersection with U.S. Route 43 (US 43) near Green Hill, an unincorporated community south of the Tennessee state line. The eastern terminus of the highway is at an intersection with SR 207 north of Anderson.

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SR 64 travels along a two-lane roadway as it travels through northern Lauderdale County. The highway connects the small towns of Anderson and Lexington with US 43, which heads southward into Florence and Muscle Shoals.

The entire route is in Lauderdale County.

Location	mi	km	Destinations	Notes
​	0.000	0.000	US 43 (SR 13) – Florence, Lawrenceburg	Western terminus
Lexington	10.111	16.272	SR 101 – Loretto, Wheeler Dam
​	18.230	29.338	SR 207 – Pulaski, Minor Hill, Anderson, Rogersville	Eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi

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