Highway 13 is an east–west highway through central Alberta. It runs from Alder Flats, 7 km (4 mi) west of Highway 22, to the Alberta-Saskatchewan border, where it becomes Saskatchewan Highway 14. Highway 13 is about 366 kilometres (227 mi) long. East of the City of Wetaskiwin, it generally parallels the Canadian Pacific Kansas City Prairie North Line.

From the west, Highway 13 begins at Alder Flats before intersecting Highway 22. It continues east, passing south of Buck Lake and Winfield before crossing Highway 20. The highway then passes south of Battle Lake, the headwaters of the Battle River, and then south of Pigeon Lake, passing through the hamlets of Westerose and Falun prior to intersecting Highway 2 (Queen Elizabeth II Highway), approximately 51 km (32 mi) south of Edmonton.

East of Highway 2, Highway 13 enters Wetaskiwin as 40 Avenue and turns north along Highway 2A (56 Street). At the north side of Wetaskiwin, it turns east and passes north of Gwynne through Bittern Lake. After crossing Highway 21, it enters Camrose as 48 Avenue.

East of Camrose, Highway 13 travels generally southeast, passing by Ohaton, Bawlf, Daysland and Strome prior to an intersection with Highway 36 (Veterans Memorial Highway) in Killam. The highway continues southeast passing by Sedgewick, Lougheed, Hardisty, Amisk and Hughenden, crossing Highway 41 north of Czar. The road travels by Metiskow, through Provost, and by Hayter. Upon entering Saskatchewan, Highway 13 continues as Saskatchewan Highway 14 to Saskatoon.

The section of Highway 13 from Wetaskiwin to Winfield was originally designated as Highway 19, but was renumbered in the late 1960s. Highway 13 was extended further west to Alder Flats in c. 1979 when Highway 612 was renumbered, coinciding with the commissioning of Highway 22 north of Cremona.

From west to east:

Rural/specialized municipality	Location	km	mi	Destinations	Notes
County of Wetaskiwin No. 10	Alder Flats	0.0	0.0	Range Road 74 / Township Road 460	Western terminus
	​	6.5	4.0	Highway 22 – Drayton Valley, Rocky Mountain House
		11.3	7.0	Range Road 63 – Buck Lake
		20.6	12.8	Highway 761 north
	Winfield	39.1	24.3	UAR 175 north
	​	39.9	24.8	Highway 20 – Breton, Rimbey
		59.3	36.8	Crosses Battle River
		63.7	39.6	Highway 771 – Pigeon Lake Provincial Park
	Westerose	69.7	43.3	Highway 13A east – Ma-Me-O Beach
	​	74.6	46.4	Highway 13A west – Ma-Me-O Beach
	Falun	82.0	51.0	Highway 795 – Calmar
	​	92.3	57.4	Highway 2 – Edmonton, Red Deer, Calgary	Interchange; Hwy 2 exit 295
City of Wetaskiwin		109.5	68.0	56 Street (Highway 2A south) – Ponoka 40 Avenue (Highway 613 east)	West end of Hwy 2A concurrency; former Hwy 13A east
		112.7	70.0	Highway 2A north – Leduc, Edmonton	East end of Hwy 2A concurrency
		114.3	71.0	Highway 814 north / 47 Street – Beaumont	Former Hwy 13A west
County of Wetaskiwin No. 10	​	124.9	77.6	Highway 822
	Gwynne	126.0	78.3	UAR 189 south
Camrose County	Bittern Lake	136.0	84.5
	Ervick	143.4	89.1	Highway 21 – Edmonton, Three Hills
City of Camrose		149.8	93.1	68 Street (Highway 13A east) – Thru Traffic	Bypass route
		151.8	94.3	51 Street (Highway 833 north)
		153.7	95.5	Highway 26 east – Viking
		155.9	96.9	Highway 13A west (Camrose Drive) – Thru Traffic	Bypass route
Camrose County	​	160.8	99.9	Highway 56 – Stettler	Former Hwy 834 north
	Ohaton	164.4	102.2	Range Road 192 – Round Hill
	Bawlf	180.3	112.0	Highway 854 – Ryley, Rosalind
Flagstaff County	Daysland	194.5	120.9	Highway 855 north – Holden	West end of Hwy 855 concurrency
	​	196.2	121.9	Highway 855 south – Heisler, Forestburg	East end of Hwy 855 concurrency
	Strome	209.0	129.9	Highway 856 south – Forestburg
	Killam	223.7	139.0	Highway 36 – Viking, Castor
	Sedgewick	234.3	145.6	Highway 869 north
	Lougheed	246.5	153.2	Highway 870 north – Kinsella
	​	257.7	160.1	Highway 872 south – Coronation
	Hardisty	263.6	163.8	Highway 881 north – Irma
	​	265.6	165.0	Crosses Battle River
M.D. of Provost No. 52	Amisk	284.4	176.7	Highway 884 south – Veteran
	Hughenden	294.1	182.7	Highway 603 west / UAR 86 east
	​	305.1	189.6	Highway 41 – Czar, Consort, Wainwright
		320.4	199.1	UAR 87 south – Metiskow
		332.9	206.9	Range Road 41 – Cadogan	Former UAR 108 south
	Provost	348.0	216.2	Highway 899 north – Ribstone Highway 600 west – Cadogan	West end of Hwy 899 concurrency
		349.6	217.2	Highway 899 south – Bodo	East end of Hwy 899 concurrency
	Hayter	358.6	222.8
	​	366.0	227.4	Highway 14 east – Macklin, Saskatoon	Continuation into Saskatchewan
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Route transition

Alberta Provincial Highway No. 13A is the designation of the following two current and one former alternate routes of Highway 13.

Ma-Me-O Beach

From 2.0 km (1.2 mi) east of Westerose to 5.6 km (3.5 mi) west of Falun, the first segment of Highway 13A travels 7.4 km (4.6 mi) through Pigeon Lake Indian Reserve 138A. It provides access to the Summer Village of Ma-Me-O Beach on the southern shore of Pigeon Lake. This segment, which runs north of Highway 13, formed the original Highway 13 alignment prior to it being realigned to bypass the Indian reserve and summer village to the south in the 2000s.

Camrose

The second segment of Highway 13A is a southern bypass of Camrose and is 8 km (5.0 mi) in length. Commissioned in 1989, the route follows 68 Street south from Highway 13 (48 Avenue) for 2.4 km (1.5 mi) and then turns east and becoming Camrose Drive, reconnecting with Highway 13 on the eastern ends of Camrose. Highway 13A serves as the main dangerous goods route through Camrose, as dangerous good are prohibited on Highway 13 (48 Avenue) through the centre of the city, and is maintained by the City of Camrose.

Wetaskiwin

Highway 13A is a former alternate route of Highway 13 through Wetaskiwin. From the present Highway 13 (west) / Highway 2A intersection, Highway 13A used to proceed east along 40 Avenue for 1.6 km (0.99 mi), then turned north and followed 47 Street for 3.2 km (2.0 mi) and reconnected with Highway 13 at the present-day Highway 13 / Highway 814 intersection. The route was decommissioned in mid-1980s.