Alphabet City is a neighborhood located within the East Village in the New York City borough of Manhattan. Its name comes from Avenues A, B, C, and D, the only avenues in Manhattan to have single-letter names. It is bounded by Houston Street to the south and 14th Street to the north, and extends roughly from Avenue A to the East River. Some famous landmarks include Tompkins Square Park, the Nuyorican Poets Cafe and the Charlie Parker Residence.

The neighborhood has a long history, serving as a cultural center and ethnic enclave for Manhattan's German, Polish, Hispanic, and immigrants of Jewish descent. However, there is much dispute over the borders of the Lower East Side, Alphabet City, and East Village. Historically, Manhattan's Lower East Side was 14th Street at the northern end, bound on the east by East River and on the west by First Avenue; today, that same area is Alphabet City. The area's German presence in the early 20th century, in decline, virtually ended after the General Slocum disaster in 1904.

Alphabet City is part of Manhattan Community District 3 and its primary ZIP Code is 10009. It is patrolled by the 9th Precinct of the New York City Police Department.

The Commissioners' Plan of 1811, which laid out the grid scheme of Manhattan above Houston Street, designated 16 north-south "avenues." Twelve numbered avenues were to run continuously to Harlem, while four lettered ones—A, B, C and D—appeared intermittently wherever the island widened east of First Avenue. The plan called for stretches of Avenue A and Avenue B north of midtown, all of which have been renamed. In 1943, Avenue A went as far north as 25th Street, Avenue B ended at 21st Street and Avenue C reached 18th Street. Stuyvesant Town, a post–World War II private residential development, blotted out the rest of A and B above 14th Street (sparing only a few blocks of Avenue C). What remained of 1811's lettered avenues came to be called, by some, Alphabet City.

There is disagreement about the earliest uses of the name. It is often characterized as a marketing invention of realtors and other gentrifiers who arrived in the 1980s. However, sociologist Christopher Mele connects the term to the arts scene of the late 1970s which in turn attracted real estate investors. As such, argues Mele, Alphabet City and its many variants—Alphaville, Alphabetland, etc.—were "playful" but also "concealed the area's rampant physical and social decline and downplayed the area’s Latino identity." Pete Hamill, a longtime New York City journalist, cites darker origins. NYPD officers, he claims, referred to the most degraded areas east of Avenue B as Alphabet City in the 1950s.

Whatever its origins, the name began to appear in print around 1980 with all three associations—crime, art, and gentrification. A December 1980 article in the Daily News reported on the eastward flow of gentrification:

Ave A. is still the DMZ. While the one side has been the East Village since the days of hippie heaven, the other side has become known, by Spanish-speaking locals, as Loisaida, and, by hand-rubbing realtors, as Alphabet City.

The Official Preppy Handbook, published in October 1980, caricatured a subgroup of preppies as "connoisseurs of punk ... who spend their weekends in alphabet city (Avenues A, B, C, and D) on the Lower East Side." Similarly, a November 1984 article in The New York Times reported "Younger artists ... are moving downtown to an area variously referred to as Alphabetland, Alphabetville, or Alphabet City (Avenues A, B, C and so forth on the Lower East Side of Manhattan)."

The term appeared in March 1983 in the New York Daily News regarding anti-drug raids in the area. It also appeared in The New York Times in an April 1984 editorial by Mayor Ed Koch justifying recent police operations:

The neighborhood, known as Alphabet City because of its lettered avenues that run easterly from First Avenue to the river, has for years been occupied by a stubbornly persistent plague of street dealers in narcotics whose flagrantly open drug dealing has destroyed the community life of the neighborhood.

In common, Mele notes, the early uses shared the "mystique of 'living on the edge.'" As early as 1989, however, a Newsday article suggested the mood, even among newcomers, had changed:

Residents call the area east of Avenue A between Houston and 14th Streets "the neighborhood," "The East Village," "The Lower East Side" or its Spanglish version, "Loisaida." That's because calling it "Alphabet City" brings too many memories of the days when outsiders began coming to Avenues A, B, C and D for the galleries, the clubs and the drugs.

Several local nickname sets associated with the ABCD denotation have included Adventurous, Brave, Crazy and Dead and, more recently by writer George Pendle, "Affluent, Bourgeois, Comfortable, Decent".

Prior to development, most of present-day Alphabet City was a salt marsh, regularly flooded by the tides of the East River (technically an estuary, not a river). Marshes played a critical role in the food web and protected the coast. The Lenape Native Americans who inhabited Manhattan before European contact presided over similar ecosystems from New York Bay to Delaware Bay. They tended to settle in forest clearings. In summer, however, they foraged shellfish, gathered cordgrass for weaving, and otherwise exploited the wetlands.

Dutch settlers brought a different model of land ownership and use. In 1625, representatives of the Dutch West India Company set their sights on lower Manhattan, with plans for a fortified town at its tip served by farms above. In 1626, they "purchased" the island from a local Lenape group and began parceling the land into boweries (from the Dutch for "farm"). The northern half of the Alphabet City area was part of Bowery Number 2. The southwest quarter was part of Bowery Number 3. Both belonged initially to the company but were soon sold to individuals. By 1663, a year before surrendering the colony to England, Director General Peter Stuyvesant had acquired the relevant part of Number 2 and much of Number 3 from other settlers. The company divided the southeast quarter of Alphabet City into small lots associated with larger parcels further away from the shore. In this way, upland farmers gained access to the unique tidal ecosystem—"salt meadow" as they called it—and with it, "salt hay," a cordgrass species valued as fodder. In his influential Description of New Netherland (1655), Adriaen van der Donck informed his fellow Dutchmen:

There [are] salt meadows; some so extensive that the eye cannot oversee the same. Those are good for pasturage and hay, although the same are overflowed by the spring tides, particularly near the seaboard. These meadows resemble the lows and outlands of the Netherlands. Most of them could be dyked and cultivated.

The Dutch, then, were singularly attuned to the potential for land reclamation. During the city's first two centuries, however, large-scale landfill was limited to the more commercial southern end of the island, particularly wharfs at the mouth of the East River. Stuyvesant and his heirs, with the help of slave labor, continued to occupy their farm as a country estate, cultivating it lightly and making few changes to the land.

After the Revolutionary War, with a surge in population and trade, the city was poised to grow northward. Around 1789, Peter Stuyvesant, great-grandson of the Director General by that name, came up with a plan for the area, mapping out streets to build and lots to sell. In doing so, he was following the precedent of landowners to the south. However, by this time, the city was laying out roads of its own and wanted to connect the whole. The first proposal for a unified street system was the Mangin–Goerck Plan. Presented in 1799, it extended Stuyvesant's grid into the cove above Alphabet City, straightening the shoreline such that Alphabet City and the Lower East Side were no longer an isolated bulge. When this plan succumbed to political squabbles and landowner demands, the city appealed to the state to dictate a design. The result was the Commissioners' Plan of 1811, setting out the street grid of Manhattan above Houston Street.

"In general," the commissioners resolved, everything "should be rectangular." However, the new roads were rotated relative to the existing ones just below Alphabet City. Moreover, the commissioners could do little to straighten the shoreline. They were limited by charter to reclaiming 400 feet beyond the low-water mark, much less than the Mangin-Goerck plan entailed. First Avenue reflected this limit. It was drawn parallel to Fifth Avenue (called Middle Road in earlier designs) as far east as possible while not straying too far into the water. Irregular bits of land protruded beyond First Avenue and, for these cases, the commissioners turned to lettered avenues. Avenues A and B appeared around Alphabet City, popped up again above midtown, and once more in Harlem (they were eventually renamed or eliminated above Alphabet City). Avenues C and D existed only in Alphabet City. Thus the neighborhood was misaligned with the old grid and relatively disconnected to the new one.

On the other hand, Alphabet City retained its long, arcing bank along the East River, just north of the ever-growing ports and shipyards that animated the city. The commissioners placed the avenues on the east side of the island closer together in anticipation of denser development there. For Alphabet City proper, they envisioned a wholesale food market supplying the entire city. It would extend from 7th to 10th Street and from First Avenue to the river, with a canal up the middle. The commissioners wrote: "The place selected for this purpose is a salt marsh, and from that circumstance, of inferior price, though in regard to its destination, of greater value than other soil."

Despite having sought a binding plan, the city requested many modifications from the state during execution, generally along lines demanded by property interests. Given the marshy environs, Alphabet City landowners, mostly Stuyvesants, argued for an extra measure of deference and the city concurred:

It is stated in the memorial [of the landowners] and the fact is unquestionable that the extensive tract of sunken meadow land lying between North Street [now Houston Street] and Brandy mulah Point [Burnt Mill Point, near 12th Street] cannot be improved with any prospect of Benefit to the Owners unless upon the most Economical Scale of Expense and under all the Encouragements which can be offered by the Corporation Consistently with the public Interests.

To this end, the proposed market place, like most of the public spaces in the plan, was returned to private hands. It was reduced to a sliver in 1815, then scrapped altogether in 1824. The city argued that the land was too remote to serve its intended purpose at the time and that holding onto it would deter development. Urban historian Edward Spann lamented, "What was perhaps the most far-sighted feature of the Plan was the first to be completely eliminated."

In the same act that abolished the market place, the state accommodated a landowner petition to narrow just the lettered avenues. From the standard avenue width of 100 feet (30 m), Avenue A was reduced to 80 feet (24 m), Avenues B, C and D to 60 feet (18 m), the width of most cross-streets. "Incapable of use as thoroughfares to and from the City," wrote the city council, "they cannot be considered as avenues in the proper Sense of the term." Instead, they should "correspond as far as possible with the Old Streets [below Houston] of which they will form the Continuation & be called by the Same names & be regulated by the Corporation as Streets."

Weighing heavily in these decisions was the marsh itself and the water that drained—or failed to drain—through it. The debate about grading and draining Alphabet City's streets went round and round for over a decade, even as filling proceeded. The standard design called for the land to slope down to the river uniformly throughout the watershed, which extended as far inland as Bowery. However, landowners, who would be assessed the cost of road construction, objected to the expense of so much landfill. In 1823, a newly created committee, with latitude to amend the 1811 plan, proposed to save money with a network of closed sewers, but these suffered a bad reputation from repeated clogging in older parts of the city. Another proposal, from a new committee, echoed the former market place design, calling for open, ornamented canals on 6th, 9th and 14th Streets. In 1832, as no amount of fill seemed to stem periodic flooding, the city resolved on a simpler sewer system. In this design, the land would slope down to Avenue C from both east and west like a trough, and flow through a sewer to the river at 14th Street (Avenue C was widened to 80 feet for the purpose). With this decided, roads and buildings went forward, though sewer construction itself would wait for decades. Archaeological excavations along Avenue C at 8th Street show that the site was incrementally raised 10–12 feet between 1820 and 1840, occupied from the 1840s (with the aid of a private cistern), and only drained by the proposed sewer line in 1867.

The Alphabet City area initially developed along the riverfront, during the 1820s, as part of the city's expanding shipbuilding and repair industry. Shipyards tended to form tight clusters in close proximity to specialized workers, such as ship carpenters, and ancillary manufacturers, such as iron works. They also required lots of cheap space. Hence, the city's growth forced the shipyards to migrate periodically to peripheral sites: above Dover Street around 1750, below Corlears Hook (some five blocks south of Houston Street) around 1800, then, beginning in the 1820s, the marshes of Alphabet City. During the 1840s and 50s, the East River, from Corlears Hook to 13th Street, and inland as far as Avenue C, represented the greatest concentration of shipbuilding activity in the country. After the Civil War, land and labor costs, along with the switch from wood to more massive iron hulls, would push the industry off the island entirely.

Shipyards first appeared along the southern end of the area's shoreline, roughly between Stanton and 3rd Street. This location was not only close to existing yards but also a relative high point. Indeed, it was called, rather confusingly, Manhattan Island, in reference to a knoll in the salt marsh, increasingly buried under wharfs. Here, in 1806-7, Charles Brownne built the first commercial steamboat, Robert Fulton's Clermont, which helped establish the city's shipbuilding reputation. Brothers Adam and Noah Brown (no relation to Charles) and Henry Eckford took over the spot and, by 1819, extended the wharf along Lewis Street, east of the new grid plan, to 5th Street. The Commissioners' Plan of 1811 called for a wholesale food market between 7th and 10th Street, but local landowners put a stop to this, clearing the way for more of the same. In 1825, a well-capitalized group of shipowners and builders formed the New York Dry Dock Company to upgrade the city's repair facilities. They bought a chunk of waterfront recently sold off by Stuyvesants, running from 6th to 13th Street, and built an elaborate campus around 10th Street including Dry Dock Bank, Dry Dock Street (present-day Szold Place), and novel marine railways to elevate ships for repair. Hence, the neighborhood as a whole was often called Dry Dock.

In 1828, an observer wrote, "No place on this island has the destroying hand of man done more to alter the face of nature... Hills of great magnitude have been entirely levelled, or cut down, and used to fill up docks and wharves." By the early 1840s, the shipyards formed a solid line along the riverfront, jutting out several hundred feet from the former low-water mark of the marsh. Shipbuilders included Smith & Dimon (4th to 5th Street), William H. Webb (5th to 7th Street), Jacob A. Westervelt (7th to 8th Street) and William H. Brown (11th to 12th Street). Alongside them were sparmakers, who built masts for the booming clipper trade, as well as iron works, which manufactured steam engines. Morgan Iron Works (9th to 10th Street) and Novelty Iron Works (12th to 14th Street) soon became the area's largest employers. Novelty had about 1200 workers at its peak in the 1850s, and was regarded as a marvel of engineering and operations.

As shipyards filled the riverfront, housing popped up nearby. In many cases, shipbuilders themselves played the role of developer. Noah Brown, for example, built a boardinghouse for apprentices south of Houston and invested in large plots to the north. Beginning around 1830, the Ficketts, another shipbuilding clan, built numerous three-story brick houses along Avenue D as well as cross streets west to Avenues C. They occupied some themselves and rented lesser variants to skilled laborers. By the early 1840s, shipyard owners dotted the neighborhood, and the majority of the city's ship carpenters lived in a narrow strip of blocks along Avenue D and Lewis Street, a stone's throw from the wharfs.

Throughout this period, the industry was dominated by in-migrants drawn to the booming shipyards from surrounding countryside and boatbuilding regions across New England. They shared a traditional production model in which artisans progressed from apprentices to journeymen to masters, all while living and working side by side. Sean Wilentz, who documented the sweatshop proclivities of antebellum New York City, points to shipbuilding as the rare industry where tradition persisted and kept wages, skill and respect generally high. He and others also credit shipyard workers with pioneering the reduction of work hours in the United States. A "Mechanics' Bell" hung for decades along the Alphabet City riverfront to enforce the ten-hour day that journeymen secured around 1834. Labor reformer George McNeill likened it to a "'Liberty Bell' ... for the sons of toil."

The Commissioners' Plan and resulting street grid was the catalyst for the northward expansion of the city, and for a short period, the portion of the Lower East Side that is now Alphabet City was one of the wealthiest residential neighborhoods in the city. Following the grading of the streets, development of rowhouses came to the East Side and NoHo by the early 1830s. In 1833, Thomas E. Davis and Arthur Bronson bought the entire block of 10th Street from Avenue A to Avenue B. The block was located adjacent to Tompkins Square Park, located between 7th and 10th Streets from Avenue A to Avenue B, designated the same year. Though the park was not in the original Commissioners' Plan of 1811, part of the land from 7th to 10th Streets east of First Avenue had been set aside for a marketplace that was ultimately never built. Rowhouses of 2.5 to 3 stories were built on the side streets by such developers as Elisha Peck and Anson Green Phelps; Ephraim H. Wentworth; and Christopher S. Hubbard and Henry H. Casey. Following the rapid growth of the neighborhood, Manhattan's 17th ward was split from the 11th ward in 1837. The former covered the area from Avenue B to the Bowery, while the latter covered the area from Avenue B to the East River.

By the middle of the 19th century, many of the wealthy had continued to move further northward to the Upper West Side and the Upper East Side. Some wealthy families remained, and one observer noted in the 1880s that these families "look[ed] down with disdain upon the parvenus of Fifth avenue." In general, though, the wealthy population of the neighborhood started to decline as many moved northward. Immigrants from modern-day Ireland, Germany, and Austria moved into the neighborhood.

The population of Manhattan's 17th ward, which included the western part of the modern Alphabet City, doubled from 18,000 people in 1840 to over 43,000 in 1850, and nearly doubled yet again to 73,000 persons in 1860, becoming the city's most highly populated ward at that time. As a result of the Panic of 1837, the city had experienced less construction in the previous years, and so there was a dearth of units available for immigrants, resulting in the subdivision of many houses in lower Manhattan. Another solution was brand-new "tenant houses", or tenements, within the East Side. Clusters of these buildings were constructed by the Astor family and Stephen Whitney. The developers rarely involved themselves with the daily operations of the tenements, instead subcontracting landlords (many of them immigrants or their children) to run each building. Numerous tenements were erected, typically with footprints of 25 by 25 feet (7.6 by 7.6 m), before regulatory legislation was passed in the 1860s. To address concerns about unsafe and unsanitary conditions, a second set of laws was passed in 1879, requiring each room to have windows, resulting in the creation of air shafts between each building. Subsequent tenements built to the law's specifications were referred to as Old Law Tenements. Reform movements, such as the one started by Jacob Riis's 1890 book How the Other Half Lives, continued to attempt to alleviate the problems of the area through settlement houses, such as the Henry Street Settlement, and other welfare and service agencies.

Because most of the new immigrants were German speakers, modern Alphabet City, East Village and the Lower East Side collectively became known as "Little Germany" (German: Kleindeutschland). The neighborhood had the third largest urban population of Germans outside of Vienna and Berlin. It was America's first foreign language neighborhood; hundreds of political, social, sports and recreational clubs were set up during this period. Numerous churches were built in the neighborhood, of which many are still extant. In addition, Little Germany also had its own library on Second Avenue in nearby East Village, now the New York Public Library's Ottendorfer branch. However, the community started to decline after the sinking of the General Slocum on June 15, 1904, in which over a thousand German-Americans died.

The Germans who moved out of the area were replaced by immigrants of many different nationalities. This included groups of Italians and Eastern European Jews, as well as Greeks, Hungarians, Poles, Romanians, Russians, Slovaks and Ukrainians, each of whom settled in relatively homogeneous enclaves. In How the Other Half Lives, Riis wrote that "a map of the city, colored to designate nationalities, would show more stripes than on the skin of a zebra, and more colors than any rainbow." One of the first groups to populate the former Little Germany were Yiddish-speaking Ashkenazi Jews, who first settled south of Houston Street before moving northward. The Roman Catholic Poles as well as the Protestant Hungarians would also have a significant impact in the East Side, erecting houses of worship next to each other along 7th Street at the turn of the 20th century. By the 1890s, tenements were being designed in the ornate Queen Anne and Romanesque Revival styles, though tenements built in the later part of the decade were built in the Renaissance Revival style. At the time, the area was increasingly being identified as part of the Lower East Side.

The New York State Tenement House Act of 1901 drastically changed the regulations to which buildings in the East Side had to conform. Simultaneously, the Yiddish Theatre District or "Yiddish Rialto" developed within the East Side, centered around Second Avenue. It contained many theaters and other forms of entertainment for the Jewish immigrants of the city. By World War I, the district's theaters hosted as many as 20 to 30 shows a night. After World War II, Yiddish theater became less popular, and by the mid-1950s few theaters were still extant in the District.

The city built First Houses on the south side of East 3rd Street between First Avenue and Avenue A, and on the west side of Avenue A between East 2nd and East 3rd Streets in 1935–1936, the first such public housing project in the United States. The Polish enclave in the East Village persisted, though numerous other immigrant groups had moved out, and their former churches were sold and became Orthodox cathedrals. Latin American immigrants started to move to the East Side, settling in the eastern part of the neighborhood and creating an enclave that later came to be known as Loisaida.

The East Side's population started to decline at the start of the Great Depression in the 1930s and the implementation of the Immigration Act of 1924, and the expansion of the New York City Subway into the outer boroughs. Many old tenements, deemed to be "blighted" and unnecessary, were destroyed in the middle of the 20th century. The Village View Houses on First Avenue between East 2nd and 6th Streets were opened in 1964, partially on the site of the old St. Nicholas Kirche.

Until the mid-20th century, the area was simply the northern part of the Lower East Side, with a similar culture of immigrant, working-class life. In the 1950s and 1960s, the migration of Beatniks into the East Village attracted hippies, musicians, writers, and artists who had been priced out of the rapidly gentrifying Greenwich Village. Among the first displaced Greenwich Villagers to stray as far east as Alphabet City was poet Allen Ginsberg, who moved to 206 East 7th Street in 1951. His apartment served as a "nerve center" for writers such as William Burroughs, Jack Kerouac and Gregory Corso. Further change came in 1955 when the Third Avenue elevated railway above the Bowery and Third Avenue was removed. This in turn made the East Side more attractive to potential residents, and by 1960, The New York Times said that "this area is gradually becoming recognized as an extension of Greenwich Village ... thereby extending New York’s Bohemia from river to river". The area became a center of the counterculture in New York, and was the birthplace and historical home of many artistic movements, including punk rock and the Nuyorican literary movement.

By the 1970s and 1980s, the city in general was in decline and nearing bankruptcy, especially after the 1975 New York City fiscal crisis. Residential buildings in Alphabet City and the East Village suffered from high levels of neglect, as property owners did not properly maintain their buildings. The city purchased many of these buildings, but was also unable to maintain them due to a lack of funds. In spite of the deterioration of the area's structures, its music and arts scenes were doing well. By the 1970s, gay dance halls and punk rock clubs had started to open in the neighborhood. These included the Pyramid Club, which opened in 1979 at 101 Avenue A; it hosted musical acts such as Nirvana and Red Hot Chili Peppers, as well as drag performers such as RuPaul and Ann Magnuson.

Alphabet City was one of many neighborhoods in New York to experience gentrification in the late 20th and early 21st centuries. Multiple factors resulted in lower crime rates and higher rents in Manhattan in general, and Alphabet City in particular. Avenues A through D became distinctly less bohemian in the 21st century than they had been in earlier decades. In the 1970s, rents were extremely low and the neighborhood was considered one of the least desirable places in Manhattan to live in. However, as early as 1983, the Times reported that because of the influx of artists, many longtime establishments and immigrants were being forced to leave the area due to rising rents. By the following year, young professionals constituted a large portion of the neighborhood's demographics. Even so, crime remained prevalent and there were often drug deals being held openly in Tompkins Square Park.

Tensions over gentrification contributed to the 1988 Tompkins Square Park riot, which occurred following opposition to a proposed curfew that had targeted the park's homeless. The aftermath of the riot slowed gentrification somewhat, as real estate prices declined. However, by the end of the 20th century, real estate prices had resumed their rapid rise. About half of Alphabet City's stores had opened within the decade since the riot, while vacancy rates in that period had dropped from 20% to 3%, indicating that many of the longtime merchants had been pushed out.

The Museum of Reclaimed Urban Space opened on Avenue C in the building known as C-Squat in 2012. An archive of urban activism, the museum explores the history of grassroots movements in the East Village and offers guided walking tours of community gardens, squats, and sites of social change.

Politically, Alphabet City is in New York's 7th and 12th congressional districts. It is also in the New York State Senate's 27th and 28th districts, the New York State Assembly's 65th and 74th districts, and the New York City Council's 1st and 2nd districts.

Local community groups such as the Greenwich Village Society for Historic Preservation (GVSHP) are working to gain individual and district landmark designations for Alphabet City to preserve and protect the architectural and cultural identity of the neighborhood. In early 2011, the New York City Landmarks Preservation Commission (LPC) proposed a small district along the block of 10th Street that lies north of Tompkins Square Park. The East 10th Street Historic District was designated by the LPC in January 2012.

Several notable buildings are designated as individual landmarks. These include:

Image	Name	Address	Year(s) built	Designation(s)
	Charlie Parker Residence	151 Avenue B between 9th and 10th Streets	1849	National Register of Historic Places (1994), New York City Landmark (1999)
	Children's Aid Society's Tompkins Square Lodging House for Boys and Industrial School aka Eleventh Ward Lodging House (former)	295 East 8th Street at Avenue B	1886	New York City Landmark (2000)
	Christodora House	143 Avenue B at 9th Street	1928	National Register of Historic Places (1986)
	Congregation Beth Hamedrash Hagadol Anshe Ungarin (former)	242 East 7th Street between Avenues C and D	1908	New York City Landmark (2008)
	Eleventh Street Methodist Episcopal Chapel (former)	543-547 East 11th Street between Avenues A and B	1867–1868	New York City Landmark (2010)
	First Houses	East 3rd Street and Avenue A	1935–1936	New York City Landmark (1974)
	Free Public Baths of the City of New York (former)	538 East 11th Street between Avenues A and B	1904–1905	New York City Landmark (2008)
	Public National Bank of New York Building	106 Avenue C at 7th Street	1923	New York City Landmark (2008)
	Public School 64 (former)	350 East 10th Street between Avenues B and C	1904–1906	New York City Landmark (2006)
	St. Nicholas of Myra Church	288 East 10th Street at Avenue A	1882–3	New York City Landmark (2008)
	Wheatsworth Bakery Building	444 East 10th Street between Avenues C and D	1927–1928	New York City Landmark (2008)

Other buildings of note include "Political Row", a block of stately rowhouses on East 7th Street between Avenues C and D, where political leaders of every kind lived in the 19th century; the landmarked Wheatsworth Bakery building on East 10th Street near Avenue D; and next to it, 143-145 Avenue D, a surviving vestige of the Dry Dock District, which once filled the East River waterfront with bustling industry.

Alphabet City has a large number of surviving early 19th century houses connected to the maritime history of the neighborhood, which also are the first houses ever to be built on what had been farmland. Despite efforts by the GVSHP to preserve these houses, the LPC has not done so. An 1835 rowhouse at 316 East 3rd Street was demolished in 2012 for the construction of a 33-unit rental called "The Robyn". In 2010, GVSHP and the East Village Community Coalition asked the LPC to consider for landmark designation 326 and 328 East 4th Street, two Greek Revival rowhouses dating from 1837–41, which over the years housed merchants affiliated with the shipyards, a synagogue, and most recently an art collective called the Uranian Phalanstery. However, the LPC has not granted these rowhouses landmark status. The LPC also declined to add 264 East 7th Street (the former home of illustrator Felicia Bond) and four neighboring rowhouses to the East Village/Lower East Side Historic District.

In 2008, nearly the entire Alphabet City area was "downzoned" as part of an effort led by local community groups including GVSHP, the local community board, and local elected officials. In most parts of Alphabet City, the rezoning requires that new development occur in harmony with the low-rise character of the area.

Loisaida /ˌloʊ.iːˈsaɪdə/ is a term derived from the Spanish (and especially Nuyorican) pronunciation of "Lower East Side". Originally coined by poet/activist Bittman "Bimbo" Rivas in his 1974 poem "Loisaida", it now refers to Avenue C in Alphabet City, whose population has largely been Hispanic (mainly Nuyorican) since the 1960s.

Since the 1940s the demography of the neighborhood has changed markedly several times: the addition of the large labor-backed Stuyvesant Town–Peter Cooper Village after World War II at the northern end added a lower-middle to middle-class element to the area, which contributed to the eventual gentrification of the area in the 21st century; the construction of large government housing projects south and east of those and the growing Latino population transformed a large swath of the neighborhood into a Latin one until the late 1990s, when low rents outweighed high crime rates and large numbers of artists and students moved to the area. Manhattan's growing Chinatown then expanded into the southern portions of the Lower East Side, but Hispanics are still concentrated in Alphabet City. With crime rates down, the area surrounding Alphabet City, the East Village, and the Lower East Side, is quickly becoming gentrified; the borders of the Lower East Side differ from its historical ones in that Houston Street is now considered the northern edge, and the area north of that between Houston Street and 14th Street is considered Alphabet City. But, because the Alphabet City term is largely a relic of a high-crime era, English-speaking residents refer to Alphabet City as part of the East Village, while Spanish-speaking residents continue to refer to Alphabet City as Loisaida.

Alphabet City is patrolled by the 9th Precinct of the NYPD, located at 321 East 5th Street. The 9th Precinct ranked 58th safest out of 69 patrol areas for per-capita crime in 2010.

The 9th Precinct has a lower crime rate than in the 1990s, with crimes across all categories having decreased by 78.3% between 1990 and 2018. The precinct reported 0 murders, 40 rapes, 85 robberies, 149 felony assaults, 161 burglaries, 835 grand larcenies, and 32 grand larcenies auto in 2018.

Alphabet City is served by two New York City Fire Department (FDNY) fire stations:

• Ladder Co. 3/Battalion 6 – 103 East 13th Street
• Engine Co. 28/Ladder Co. 11 – 222 East 2nd Street

Alphabet City is located within the ZIP Code 10009. The United States Postal Service operates two post offices near Alphabet City:

• Peter Stuyvesant Station – 335 East 14th Street
• Tompkins Square Station – 244 East 3rd Street

• Louis Abolafia (1941-1995) — artist, social activist, folk figure, and hippie candidate for President of the United States
• Joaquín Badajoz (born 1972) — poet, writer
• David Byrne, (born 1952) — musician, artist
• Cro-Mags - hardcore punk band
• Rosario Dawson (born 1979) — Cuban/Puerto Rican American actress
• Bobby Driscoll (1937-1968) — actor
• Eden and John's East River String Band - musicians who sometimes record and perform with cartoonist / musician Robert Crumb
• Allen Ginsberg (1926-1997) — poet, 206 E. 7th Street
• Luis Guzman (born 1956) — Puerto Rican actor
• Jonathan Larson (1960-1996) — composer and playwright, resident during the 80s & 90s
• Leftöver Crack (formed 1998) — punk rock band
• John Leguizamo (born 1964) — Hispanic actor, stand-up comedian, filmmaker, playwright
• Madonna (born 1958) — singer
• Charlie Parker (1920–1955) — jazz musician lived at 151 Avenue B between East 9th and East 10th Streets
• Geraldo Rivera (born 1943) — television personality, resident during the late 60s - early 70s
• Kiki Smith (born 1954) — artist
• John Spacely (died 1993) — musician, actor, and nightlife personality
• The Strokes (formed 1998) — rock band
• William H. Webb (1816-1899) — shipbuilder and philanthropist
• Bruce Willis — actor, resident during the early 1980s

• Community gardening
• Dos Blockos
• Museum of Reclaimed Urban Space
• Nuyorican Poets Cafe
• Riis Houses
• St. Brigid's Church

• Alphabet City: The ABCs of Gentrification, Karin Pekarchik, BusinessWeek, June 11, 2001