Amos Palmer House is a historic farmhouse located in Lower Makefield Township, Bucks County, Pennsylvania. The original section was built about 1760, and is a two-story, double pile brick structure on a stone foundation. The house subsequently had four additions: a 2+1⁄2-story, single pile stone structure built about 1810; a 1+1⁄2-story, stone and rubble structure and frame shed roofed kitchen added about 1870; a two-story, frame kitchen addition built about 1900; and a small frame shed dated between about 1940 and 1980. The house is in the Georgian style.

It was added to the National Register of Historic Places in 1988.