Ampelonas (Greek: Αμπελώνας, Greek pronunciation: [abe'lonas]) is a village and a municipal unit of the Tyrnavos municipality. Before the 2011 local government reform it was an independent municipality. The community of Ampelonas covers an area of 38.632 km while the respective municipal unit covers an area of 154.759 km.

The municipali unit of Ampelonas consists of four communities:

• Ampelonas (population 6,083)
• Deleria (population 655)
• Rodia (population 732)
• Vryotopos (population 585)

Ampelonas was founded in the first quarter of the 15th century, when the Ottoman sultan Murad II settled 5,000–6,000 Yörüks from Konya in the area of Ampelonas. Following the 1881 Convention of Constantinople and the cession of Thessaly to Greece, the Turks of the village sold their properties and immigrated to Asia Minor, while Greeks moved in the area. Until 1928 the village was named Kazaklar (Greek: Καζακλάρ, Greek pronunciation: [kazak'laɾ]).

Ampelonas is a rural area and its main products are grapes, wine and tsipouro. Ampelonas Wine Festival is held annually in the village since 1959. Cotton, cereals, corn, almonds, pears and peaches are grown in the area. Moreover, there are cultivations of fruits and vegetables like cabbages, peppers, tomatoes, melons and watermelons.

Historical population

Year	Pop.	±%
2001	8,463	—
2011	8,055	−4.8%
2021	7,257	−9.9%

• List of settlements in the Larissa regional unit