Ampilly-le-Sec is a commune in the Côte-d'Or department in the Bourgogne-Franche-Comté region of eastern France.

Ampilly-le-Sec is located some 5 km south by south-west of Chatillon-sur-Seine and 15 km east by south-east of Laignes. It can be accessed by the D980 highway from Chatillon-sur-Seine which passes through the village and continues south to Coulmier-le-Sec. The D971 from Buncey to Chamesson also passes through the eastern edge of the commune. From the D971 the D29A goes west through the village then continues to the south-west. The western third of the commune is heavily forested with the rest being entirely farmland.

The Seine River passes through the east of the commune parallel to the D971 flowing from south to north.

Blazon: Azure, two stag's heads caboshed of Or posed in pale, in chief argent charged with three millwheels of gules.

This list is incomplete; you can help by adding missing items. (April 2021)

List of Successive Mayors

From	To	Name
2001	2026	René Regnault

The inhabitants of the commune are known as Ampilliaciens or Ampilliaciennes alternatively Ampellois or Ampelloises in French.

Historical population

Year Pop. ±% p.a. 1793 476 —     1800 517 +1.19% 1806 536 +0.60% 1821 536 +0.00% 1831 525 −0.21% 1836 645 +4.20% 1841 664 +0.58% 1846 603 −1.91% 1851 590 −0.43% 1856 626 +1.19% 1861 548 −2.63% 1866 605 +2.00% 1872 577 −0.79% 1876 553 −1.06% 1881 570 +0.61% 1886 560 −0.35% 1891 505 −2.05% 1896 449 −2.32%	Year Pop. ±% p.a. 1901 468 +0.83% 1906 416 −2.33% 1911 416 +0.00% 1921 365 −1.30% 1926 337 −1.58% 1931 413 +4.15% 1936 372 −2.07% 1946 356 −0.44% 1954 386 +1.02% 1962 353 −1.11% 1968 333 −0.97% 1975 360 +1.12% 1982 384 +0.93% 1990 424 +1.25% 1999 377 −1.30% 2007 372 −0.17% 2012 366 −0.32% 2017 348 −1.00%
Source: EHESS and INSEE

The commune has a number of buildings and structures that are registered as historical monuments:

• A Blast Furnace (1829)
• A House at Rue de Coulmier (19th century)
• A House at Rue de la Maison Commune (19th century)
• The Town Hall/School at Rue de la Maison Commune (19th century)
• An old Ironworks (1833)
• Houses (19th century)

The commune has several religious buildings and sites that are registered as historical monuments:

• A Wayside Cross at CR 12 (18th century)
• A Tomb at CR 25 (19th century)
• A Cemetery Cross at CR 25 (19th century)
• A Cemetery Chapel at CR 25 (19th century)
• A Wayside Cross at CR 8 (18th century)
• A Wayside Cross at CVO2 and CR32 crossroads (1840)
• A Wayside Cross at Rue de Chamesson and CR13 crossroads (1811)
• A Cemetery at Rue de l'Église (19th century)
• The Parish Church of Saint Peter and Paul at Rue de l'Église (1827). The Church contains a large number of items that are registered as historical objects.
• A Wayside Cross at RD 29a (1877)
• A Wayside Cross at RD29a and CR 25 crossroads (1762)
• A Wayside Cross at RN 71 and former Chemin de Chamesson crossroads at Vanvey (1861)
• A Wayside Cross at Grande Rue and Rue de la Croix de Mission crossroads (19th century)
• A Monumental Cross (1638)
• A Wayside Cross at Ferme de la Forêt (1783)
• A Wayside Cross at Ferme de la Forfol (18th century)

• Communes of the Côte-d'Or department

• Ampilly-le-Sec on the National Geographic Institute website (in French)
• Ampilly-le-Sec on Géoportail, National Geographic Institute (IGN) website (in French)
• Ampilly on the 1750 Cassini Map