Amyderýa Nature Reserve (Turkmen: Amyderýa goraghanasy) is a nature reserve (zapovednik) of north-eastern Turkmenistan.

Established in 1982 to protect part of the Amu Darya River, it is located in the north-east of Lebap Province and covers an area of 495 km.

It also incorporates one sanctuary:

• Kelif Sanctuary - established in 1970.