Ankofabe is a town and commune (Malagasy: kaominina) in Madagascar. It belongs to the district of Maroantsetra, which is a part of Analanjirofo Region. The population of the commune was estimated to be approximately 10,561 in 2018.

Primary and junior level secondary education are available in town. The majority 95% of the population of the commune are farmers. The most important crops are rice and vanilla, while other important agricultural products are coffee and cloves. Services provide employment for 5% of the population.

15°30′S 49°37′E / 15.500°S 49.617°E / -15.500; 49.617