Antioch is an unincorporated community in Cass County, Texas, United States. According to the Handbook of Texas, the community had a population of 45 in 2000.

Antioch grew up around a church from 1856 and was originally called Anti. A post office was established in 1888 and remained in operation until 1904, with a brief closure from 1889 to 1901. The community had a church, a cemetery, and several scattered houses in 1936. It had 29 residents served by two businesses, a church, and a cemetery in 1983. The population remained at 29 in 1990 then grew to 45 in 2000.

Antioch is located on Farm to Market Roads 96 and 2791, 7 mi (11 km) northwest of Atlanta in northeastern Cass County.

Antioch had its own school in 1936. Today, the community is served by the Queen City Independent School District.