Antsalaka or Antsalaka Atsimo is a town and commune (Malagasy: kaominina) in northern Madagascar. It belongs to the district of Antsiranana II, which is a part of Diana Region. The population of the commune was estimated to be approximately 4,000 in 2001 commune census.

Only primary schooling is available. The majority 99.8% of the population of the commune are farmers. The most important crop is beans, while other important agricultural products are maize and rice. Services provide employment for 0.2% of the population.

12°38′S 49°15′E / 12.633°S 49.250°E / -12.633; 49.250