Antsiranambe is a town and commune in Madagascar. It belongs to the district of Farafangana, which is a part of Atsimo-Atsinanana Region. The population of the commune was estimated to be approximately 3,000 in 2001 commune census.

Only primary schooling is available. The majority 94.5% of the population of the commune are farmers, while an additional 5% receives their livelihood from raising livestock. The most important crop is rice, while other important products are cassava and sweet potatoes. Services provide employment for 0.5% of the population.

23°9′S 47°42′E / 23.150°S 47.700°E / -23.150; 47.700