The Apostolic Prefecture of Misurata is a Latin Church missionary territory or apostolic prefecture of the Catholic Church in Misurata, Libya. It is exempt to the Holy See and not part of any ecclesiastical province. The apostolic prefecture has been vacant since 1969.

The Prefecture was established on 22 June 1939, on territory split from the Apostolic Vicariate of Tripolitana (now renamed Tripoli).

All Friars Minor (O.F.M.) and from Italy

Apostolic Prefects of Misurata

• Vitale Bonifacio Bertoli (O.F.M.) (20 February 1948 – 5 April 1951; later Titular Bishop of Attæa and Apostolic Vicar of Tripolitana)
• Illuminato Colombo, O.F.M. (20 April 1951 – 1957)
• Guido Attilio Previtali, O.F.M. (5 December 1958 – 26 June 1969)
• Apostolic administrator Guido Attilio Previtali (4 August 1969 – 3 May 1985), Titular Bishop of Sozusa in Libya, Apostolic Vicar of Tripoli

• Roman Catholicism in Libya

• GigaCatholic

32°23′02″N 15°04′48″E / 32.3840°N 15.0800°E / 32.3840; 15.0800