Appleby's Methodist Church is a historic Methodist church located near St. George, Dorchester County, South Carolina. It was probably built about 1840–1850, and is a one-story, wooden meeting house in the Greek Revival style. The building is clapboard and the medium gable roof is covered with asphalt shingles. Also on the property is a contributing late 19th-century cemetery.

It was built in 1840 and added to the National Register in 1978.