Appleton railway station served a primarily industrial area of Widnes, England. It was located on the southern section of the former St Helens and Runcorn Gap Railway.

The station was opened by the St Helens and Runcorn Gap Railway which was later absorbed by the London and North Western Railway. The L&NWR in turn became part of the London Midland and Scottish Railway at the Grouping of 1923. The station then passed to the London Midland Region of British Railways on nationalisation in 1948, only to be closed by the British Transport Commission three years later. The line continued in freight use until 1981.

The site is buried under the A557 road. The nearest notable landmark to the station site is the Commercial Inn public house.

In 1922 ten trains called at the station in each direction, Monday to Saturday, plying between St Helens Shaw St and Ditton Junction via Widnes South. Some trains continued to Runcorn and some to Liverpool Lime Street. All trains were 3rd Class only. No trains called on Sundays.

In 1951 the service was sparser but more complex. Six trains called in each direction, Monday to Friday, the early morning ones providing both 1st and 3rd Class accommodation. On Saturdays four trains called in each direction, 3rd Class only. No trains called on Sundays.

Preceding station	Historical railways			Following station
Farnworth & Bold Line and station closed		London and North Western Railway St Helens and Runcorn Gap Railway		Ann Street Halt Line and station closed

• Butt, R. V. J. (October 1995). The Directory of Railway Stations: details every public and private passenger station, halt, platform and stopping place, past and present (1st ed.). Sparkford: Patrick Stephens Ltd. ISBN 978-1-85260-508-7. OCLC 60251199. OL 11956311M.
• Bradshaw, George (1985) [July 1922]. Bradshaw's General Railway and Steam Navigation guide for Great Britain and Ireland: A reprint of the July 1922 issue. Newton Abbot: David & Charles. ISBN 978-0-7153-8708-5. OCLC 12500436.
• Pixton, Bob (1996), The Archive Photographs Series Widnes and St Helens Railways, The Chalford Publishing Company, ISBN 978-0-7524-0751-7
• Smith, Paul; Turner, Keith (2012), Railway Atlas Then and Now, Ian Allan Publishing, ISBN 978-0-7110-3695-6
• Suggitt, Gordon (2004). Lost Railways of Merseyside and Greater Manchester. Newbury: Countryside Books. ISBN 978-1-85306-869-0.

• The station on an 1888-1913 Overlay OS Map via National Library of Scotland
• The station on an old OS map via npe maps
• The station via Disused Stations UK
• an illustrated history of the line via 8D Association