Highway 259 (AR 259, Ark. 259, and Hwy. 259) is a designation for three north–south state highways in northeast Arkansas. A southern route of 12.11 miles (19.49 km) runs north from Highway 238 to US Route 70 (US 70) at Lake Grove, Arkansas. A second route of 6.90 miles (11.10 km) begins at Highway 306 and runs north to Highway 284 in Cross County. A third route of 3.14 miles (5.05 km) begins at Highway 364 and runs north to Highway 42 near Hickory Ridge.

Highway 259 begins at Highway 238 west of Moro and runs north past a cemetery before turning east and meeting Highway 78 at South Plains. The two routes have a brief concurrency north before Highway 78 splits to the northwest and Highway 259 continues north. Shortly after this junction, Highway 259 serves as the southern terminus for Highway 261. The highway runs north through New Salem before entering St. Francis County, where it terminates at US 70.

Highway 259 begins in the northwest corner of St. Francis County at Highway 306 and runs due north through flat farmland. The route runs into Cross County where it terminates at Highway 284. The highway does not cross or overlap with any other state highways and essentially serves as a connector route between two rural routes.

Highway 259 begins at Highway 364 in eastern Cross County. The route runs north through farmland to Highway 42 in Hickory Ridge, where it terminates.

Mile markers reset at concurrences.

County	Location	mi	km	Destinations	Notes
Lee	​	0.00	0.00	AR 238 – Brinkley, Moro	Southern terminus
	South Plains	0.00	0.00	AR 78 east – Moro	Southern end of AR 78 concurrency
		0.00	0.00	AR 78 west – Wheatley	Northern end of AR 78 concurrency
		0.43	0.69	AR 261 north – Holub	Southern terminus of AR 261
St. Francis	Lake Grove	12.11	19.49	US 70 – Brinkley, Forrest City	Northern terminus
	Gap in route
	​	0.00	0.00	AR 306	Southern terminus
Cross	​	6.90	11.10	AR 284 – Wynne	Northern terminus
	Gap in route
	​	0.00	0.00	AR 364	Southern terminus
	Hickory Ridge	3.14	5.05	AR 42 – Hickory Ridge, Cherry Valley	Northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• List of state highways in Arkansas

Media related to Arkansas Highway 259 at Wikimedia Commons