Highway 160 (AR 160, Ark. 160, and Hwy. 160) is a designation for four state highways in South Arkansas. The northernmost segment of 51.55 miles (82.96 km) runs from Farm to Market Road 249 at the Texas state line near Bloomburg, Texas east to Highway 19 at Macedonia. A second segment of 14.73 miles (23.71 km) runs east from Highway 57 east to Highway 7 Business in Smackover. In southern Calhoun County, Highway 160 begins at US Route 278 (US 278) and runs east to US 425 in Fountain Hill. A fourth segment begins at US 82 and runs 22.73 miles (36.58 km) east to US 65 at Chicot Junction.

Highway 160 begins at State Line Avenue as Farm to Market Road 249 near Bloomburg, Texas and heads east to a junction with Highway 237 before a junction with US 71 near Doddridge. The route runs underneath Interstate 49 before it crosses the Red River to enter Lafayette County. The route continues east, passing Gin City where it meets Highway 360, Conway Cemetery on the National Register of Historic Places, and Highway 29 in Bradley. Highway 160 heads southeast around Lake Erling before forming a concurrency north with Highway 53 to Walker Creek.

The route enters Columbia County near Taylor where it forms a 0.13 miles (0.21 km) officially designated exception over US 371 before continuing northeast to Macedonia where it terminates at Highway 19.

Highway 160 begins at Highway 57 in Mount Holly in the northwest corner of Union County. The route runs northeast to a junction with Highway 7 outside Smackover before entering the city limits. Highway 160 terminates at Highway 7 Business (7th Street) near Smackover High School.

Arkansas Highway 160 travels south until meeting AR 172, after which it begins to arrow east to join with US 63/AR 15. The merge continues until Hermitage, when AR 160 continues south past Ingalls and Vick (crossing the Fordyce & Princeton Railroad). The route then angles north towards Highway 8 in Johnsville. Beyond Johnsville, AR 160 becomes concurrent with AR 133 until Fountain Hill, where it terminates.

Mile markers reset at some concurrencies.

County	Location	mi	km	Destinations	Notes
Miller	​	0.00	0.00	FM 249 west	Continuation into Texas
	​	2.04	3.28	AR 237 north – Texarkana	AR 237 southern terminus
	Doddridge	8.98	14.45	US 71 – Texarkana, Shreveport, LA
Red River		11.96– 12.37	19.25– 19.91	Bridge
Lafayette	Gin City	20.75	33.39	AR 360 east – Canfield	AR 360 western terminus
	Bradley	25.48	41.01	AR 29 (Express Avenue) – Lewisville, Plain Dealing, LA
	​	35.20– 0.00	56.65– 0.00	AR 53 – Springhill, LA, Stamps
Columbia	Taylor	3.41– 3.54	5.49– 5.70	US 371 (Long Avenue/Hays Avenue) – Springhill, LA, Magnolia	officially designated exception
	Macedonia	16.48	26.52	AR 19 – Magnolia, Shongaloo, LA	Eastern terminus
Gap in route
Union	​	0.00	0.00	AR 57	Western terminus
	​	13.41	21.58	AR 7 (Smackover Highway) – Camden, El Dorado
	Smackover	14.73	23.71	AR 7B (Seventh Street)	Eastern terminus
Gap in route
Calhoun	Harrell	0.00	0.00	US 278 (Central) – Banks, Hampton	Western terminus
	​	5.32	8.56	AR 172 west	AR 172 eastern terminus
Bradley	​	15.07	24.25	US 63 south – Moro Bay State Park	Begin US 63 overlap north
	Hermitage	0.00	0.00	US 63 north / US 63B north (Main Street) – Warren	End US 63 overlap, US 63B southern terminus
	Johnsville	17.52	28.20	AR 8 west – Fountain Hill, Warren	Begin AR 8 overlap
Ashley	​	0.00	0.00	AR 8 east – Crossett	End AR 8 overlap
	​	1.86	2.99	AR 133 north	AR 133 southern terminus
	Fountain Hill	6.41	10.32	US 425 – Monticello, Hamburg	Eastern terminus
	Gap in route
	​	0.00	0.00	US 82 – Hamburg, Montrose	Western terminus
	Portland	7.10	11.43	AR 902 west (Main Street) – Wilson Lake Public Access	AR 902 eastern terminus
		7.35	11.83	US 165 – Dermott, Parkdale
Chicot	Chicot Junction	22.73	36.58	US 65 / Great River Road – Lake Village, Eudora	Eastern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• List of state highways in Arkansas

Media related to Arkansas Highway 160 at Wikimedia Commons