Arkansas Highway 325 (AR 325, Hwy. 325) is a north–south state highway in Mississippi County, Arkansas. The route of 5.00 miles (8.05 km) runs from US 61 in Osceola north through the city to terminate at Highway 158.

AR 325 runs north from US 61 south of Osceola. The route intersects Highway 239 before it forms a concurrency with US 61 for 0.7 miles (1.1 km). Highway 325 passes the Hale Avenue Historic District, City Hall, and the Florida Brothers Building all listed on the National Register of Historic Places. The route also passes within a block of the Mississippi County Courthouse.

Another overlap begins westbound with AR 119 for another 0.7 miles (1.1 km). AR 325 then runs due north to terminate at AR 158 at the New Salem Cemetery east of Interstate 55 and Victoria.

The entire route is in Mississippi County.

Location	mi	km	Destinations	Notes
Osceola	0.00	0.00	US 61	southern terminus
	0.45	0.72	AR 239
	1.50	2.41	US 61 east (Keiser Avenue)
	See US 61 and AR 119
	0.00	0.00	AR 119 south (Semmes Avenue)
​	3.50	5.63	AR 158	northern terminus
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

• List of state highways in Arkansas