Arkansas Highway 35 is a northwest–southeast state highway in southeast Arkansas. The route runs 115.83 miles (186.41 km) from Dewey near the Mississippi River northwest to Arkansas Highway 5 in Benton.

The route begins in Dewey at Macon Lake Road near Island number 81 on the Mississippi River. AR 35 runs through bayous and fields in Chicot County, briefly entering Desha County for a junction with AR 159/AR 208 in Halley.

Returning to Chicot County, AR 35 intersects the four-lane divided US 65/US 278 and US 165 east of Dermott, before entering the city. AR 35 serves Dermott as Speedway St before entering Drew County. The highway runs south of the Seven Devils Swamp WMA along the Arkansas Midland Railroad tracks until Monticello. AR 35 is concurrent with US 278, and later US 425 until the northwest corner of Monticello, where AR 35 turns northwest away from US 425. The highway continues northwest, intersecting AR 530, which is an under-construction segment of the future Monticello Bypass (the bypass itself is a portion of the long-term plan to extend Interstate 69 through Arkansas). A sign exists at where AR 32 will meet I-69 that states "Future I-69 Corridor <--->".

AR 35 continues northwest to enter Cleveland County, where a concurrency with US 63 begins north to Pansy. After Pansy, AR 35 runs northwest through Toledo to Rison, where it passes the American Legion Hut, Texaco Service Station, and Cities Service Station, each on the National Register of Historic Places. East of downtown, AR 35 has a junction with US 79, after which the route serves the rural northwest corner of the county.

The route next enters Grant County, passing through forest/clear cut land to a rural junction with AR 190. West of the AR 190 intersection, AR 35 begins a northbound concurrency with US 167 at Crossroads. This concurrency includes the city of Sheridan including a junction with US 270/AR 46. AR 35 turns west onto West Vine Street, ending the concurrency with US 167. The route runs northwest through rural country, entering Saline. Running past the brine springs for which the county is named, AR 35 enters Benton. In the city, the highway passes near the Gann Row Historic District, the Saline County Courthouse, and the Independent Order of Odd Fellows Building, all NRHP properties. After a large intersection with I-30/US 67/US 70/AR 5, AR 35 continues north to terminate at AR 5 in north Benton.

County	Location	mi	km	Destinations	Notes
Chicot	Dewey	0.0	0.0	Macon Lake Road
Desha	Halley	8.4	13.5	AR 159 north / AR 208 east – Yellow Bend Port
Chicot	Halley Junction	11.4	18.3	US 65 / US 278 / Great River Road – Lake Village, McGehee
	Dermott	13.3	21.4	US 165 – Montrose, McGehee
	Monticello			US 278B / Future I-69	Monticello Bypass opened October 11, 2018; Future I-69
Drew		36.4	58.6	US 278 – Monticello, McGehee
	Gap in route
	​	0.0	0.0	US 425 – Pine Bluff, Monticello
	​	5.2	8.4	AR 530 south – Wilmar	Future I-530
Cleveland	Rye	12.7	20.4	US 63 south – Warren	South end of US 63 overlap
	Pansy	0.0	0.0	US 63 north / AR 11 north – Pine Bluff, Star City	North end of US 63 overlap
	Toledo	14.1	22.7	AR 114 east – Calmer
	Rison	16.4	26.4	AR 133 north (East Magnolia Street)
		17.3	27.8	US 79 – Fordyce, Pine Bluff
	Staves	25.4	40.9	AR 212 east to US 79
Grant	​	39.7	63.9	AR 190 east
	Cross Roads	43.2	69.5	US 167 – Fordyce, Sheridan
	Gap in route
	Sheridan	0.0	0.0	US 167B (Rock Street) – Little Rock, Fordyce
	​			US 167 – El Dorado, Little Rock
Saline	​	16.3	26.2	AR 190 west – Tull
	Benton	21.4	34.4	AR 183 north (Edison Avenue) / Benton Parkway – Bauxite
		23.3	37.5	AR 88 east (Military Road)
		23.8	38.3	I-30 (US 67 / US 70) / AR 5 – Texarkana, Little Rock	Interchange; I-30 exit 117
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus       Unopened

• List of state highways in Arkansas

Media related to Arkansas Highway 35 at Wikimedia Commons