Arkansas Highway 1 (AR 1) is a designation for three state highways in east Arkansas. One segment of 30.8 miles (49.6 km) runs from U.S. Route 278 (US 278) in McGehee north to US 165 at Back Gate. A second segment of 34.3 miles (55.2 km) runs from US 165 in DeWitt north to US 49 in Marvell. A third segment of 95.8 miles (154.2 km) runs from US 49 at Walnut Corner north to the Missouri state line. One of the original 1926 state highways, Highway 1 has remained very close to its original routing.

Highway 1 begins at US 278 in downtown McGehee and runs northwest (along the Union Pacific Railroad tracks) for three blocks before turning northeast at an intersection with Highway 159. The highway continues across US 65/US 165 and exits town in a northeastern direction, passing McGehee High School. Highway 1 meets Highway 4, which runs south to Arkansas City before curving north to Rohwer, which was a Japanese American internment camp during World War II. Highway 1 passes the Kemp Cotton Gin Historic District, Rowher Relocation Center, and Rohwer Relocation Center Memorial Cemetery. Continuing north, Highway 1 ceases following the railroad at Watson and runs west to US 165 at Back Gate, where it terminates.

The route begins at US 165 and Highway 1B in DeWitt and runs east. Highway 1 bypasses southeast DeWitt, and after reconnecting with Highway 1B continues northeast. Highway 1 runs east through St. Charles before entering Monroe County. Highway 1S enters St. Charles, and terminates near the site of the Battle of Saint Charles on the White River.

Highway 1 enters southern Monroe County briefly. At Cross Roads, Highway 1 is the southern terminus of Highway 17. On the Monroe/Phillips County line, Highway 1 has a junction with Highway 39 and Highway 316. The route continues northeast to US 49 in Marvell, where it terminates.

The route begins at US 49 and Highway 85 at Walnut Corner and runs north. At the corner, Highway 1 turns north past the Richardson-Turner House and enters Lee County. The route has a junction with Highway 121 at Cypress Corner and continues north to Marianna.

In Marianna, Highway 1 breaks west from Highway 1B, which runs downtown through Marianna. After Highway 1B rejoins the main route, there is a 0.2 miles (0.32 km) concurrency north with US 79. Further north, Highway 1 passes Lee County Senior High and becomes four lanes briefly until Forrest City. Upon entering St. Francis County, Highway 1 enters Forrest City. The business route runs downtown, while the main route skirts the southwest edge of town. There is a parclo interchange with US 70 and an interchange with Interstate 40 (I-40). The business route meets Highway 1 in north Forrest City, and Highway 1 enters Caldwell and Colt before entering Cross County. South of Caldwell, Highway 1 is near the historic Little Telico Creek Bridge, listed on the National Register of Historic Places.

Highway 1 enters Wynne in Cross County. The highway has a junction with US 64, Highway 284, Highway 980, and US 64 Business, and also passes near Wynne High School. The highway continues north to Vanndale and Cherry Valley before entering Poinsett County. The route passes through marshes in southern Poinsett County before entering Harrisburg. Throughout the county, Highway 1 is paralleled by Highway 163 approximately 2.5 miles (4.0 km) to the east and US 49 approximately 10 miles (16 km) to the west, with the Union Pacific Railroad also near. Highway 1 passes the Bacon Hotel in south Poinsett County near Whitehall, and also passes the historic Modern News Building in downtown Harrisburg.

Entering Craighead County, Highway 1 enters Jonesboro from the south. After intersecting Highway 163, the route intersects I-555 (concurrent at that freeway portion with US 49). Highway 1 becomes concurrent north with US 49 (and later US 62) until Piggott

The route leaves US 62 (Crowley's Ridge Parkway) in Piggott and runs east to the Missouri state line, where it continues as Supplemental Route BB.

The route now known as Highway 1 first appears as a state highway in 1924, when the Arkansas General Assembly first created a state highway system. Arkansas State Road B-1 ran from the Louisiana state line near Wilmot north into Missouri, and was mostly unpaved. Upon creation of the U.S. Route system in 1925, the north and south portions of the highway were replaced by US 67 and US 165, respectively, shaping a more familiar Highway 1 routing. Arkansas followed the trend to number in 1926, and B-1 became Arkansas Highway 1. The route remains very true to that original course today. The route was split apart in 1941 into Highway 1 East and Highway 1 West segments from Paragould north. Highway 1 East continued north through Marmaduke and Rector. Highway 1 West traveled into Corning. By 1955, Highway 1W became Highway 135, and Highway 1E became Highway 1. US 49 overlapped Highway 1 from Jonesboro to Piggott in 1978.

This section is missing mileposts for junctions. Please help by adding them.

Mile markers reset at some concurrencies.

County	Location	mi	km	Destinations	Notes
Desha	McGehee	0.0	0.0	US 278 to US 65 – Arkansas City, Monticello	Southern terminus
		0.3	0.48	AR 159 north	Southern terminus of AR 159
		0.8	1.3	AR 1Y north to US 65 / US 165	Southern terminus of AR 1Y
	​	10.0	16.1	AR 4 west	Eastern terminus of AR 4
	Kelso	14.7	23.7	AR 138 west – Winchester	Eastern terminus of AR 138
	Pea Ridge	27.5	44.3	AR 277 south	Northern terminus of AR 277
	Back Gate	30.8	49.6	US 165 – Arkansas Post National Memorial	Northern terminus
Gap in route
Arkansas	DeWitt	0.0	0.0	US 165 – Dumas, Stuttgart	Southern terminus
		0.2	0.32	AR 1B north (South Monroe Street) – DeWitt Business District	Southern terminus of AR 1B
		2.0	3.2	AR 1B south (East 2nd Street) – DeWitt	Northern terminus of AR 1B
	​	6.0	9.7	AR 153 south to AR 17	Northern terminus of AR 153
	​	10.2	16.4	AR 153 north – Crocketts Bluff	Southern terminus of AR 153
	St. Charles	14.2	22.9	AR 17 south – Ethel	Northern terminus of AR 17
		15.6	25.1	AR 1S north – St. Charles	Southern terminus of AR 1S
Monroe	Cross Roads	21.5	34.6	AR 17 north – Holly Grove	Southern terminus of AR 17
	​	26.2	42.2	AR 39 north / AR 316 north – Turner, Watkins Corner	Southern termini of AR 39 and AR 316
Phillips	​	31.6	50.9	AR 318 south – Cypert	Northern terminus of AR 318
	Marvell	34.3	55.2	US 49 – Brinkley, Walnut Corner, Helena–West Helena	Northern terminus
	Gap in route
	Walnut Corner	0.0	0.0	US 49 / AR 85 south to AR 44 – Marvell, Helena–West Helena, Delta Cultural Center	Southern terminus; northern terminus of AR 85
	Lexa Junction	3.1	5.0	AR 242 east – Lexa	Western terminus of AR 242
Lee	Cypress Corner	7.1	11.4	AR 121 south – Rondo, LaGrange	Northern terminus of AR 121
	​	11.2	18.0	AR 243 south – Rondo	Northern terminus of AR 243
	Marianna	14.0	22.5	AR 1B north – Marianna Business District, Mississippi River State Park	Southern terminus of AR 1B
		15.5	24.9	US 79 south / AR 1B south – Pine Bluff, Marianna Business District, Mississippi River State Park	South end of US 79 overlap; southern terminus of AR 1B
		0.0	0.0	US 79 north – Hughes	North end of US 79 overlap
	​	1.8	2.9	AR 243 south	Northern terminus of AR 243
	Felton	2.6	4.2	AR 121 north – Holub	Southern terminus of AR 121
	Haynes			AR 131 north – Lee County WMA	Southern terminus of AR 131
St. Francis	​	12.7	20.4	AR 1B north – Wynne, Forrest City	Southern terminus of AR 1B
	Forrest City	16.5	26.6	US 70 – Forrest City, Palestine	Interchange
	​	18.6	29.9	I-40 – Brinkley, Little Rock, Memphis	Exit 239 on I-40
	Forrest City	21.2	34.1	AR 1B south – Forrest City	Northern terminus of AR 1B
	Caldwell	22.5	36.2	AR 261 south	Northern terminus of AR 261
	Colt	26.5	42.6	AR 306 (Old Military Road)
Cross	Wilkins	28.8	46.3	AR 350 west to AR 284	Eastern terminus of AR 350
	Wynne	33.1	53.3	AR 284 west (Union Avenue) – Business District, Cross County Museum	South end of AR 284 overlap
		33.3	53.6	US 64B east / AR 284 east (Hamilton Avenue) – Village Creek State Park	North end of AR 284 overlap; western terminus of US 64B
		33.7	54.2	AR 980 (Bridges Avenue) – Airport
		35.2	56.6	US 64 east – Memphis, West Memphis	South end of US 64 overlap
		0.0	0.0	US 64 west / US 64S south – Bald Knob	North end of US 64 overlap; northern terminus of US 64S
	Vanndale	4.3	6.9	AR 1B east / AR 364 – Tilton, Vanndale	Western terminus of AR 1B
		5.1	8.2	AR 1B west – Vanndale	Eastern terminus of AR 1B
	Cherry Valley	11.0	17.7	AR 1B north / AR 42 – Hickory Ridge, Cherry Valley, Arkansas State Veterans Cemetery	Southern terminus of AR 1B
		12.0	19.3	AR 1B south – Cherry Valley Business District	Northern terminus of AR 1B
Poinsett	​	16.4	26.4	AR 214 west – Fisher	Eastern terminus of AR 214
	Harrisburg	21.5	34.6	AR 322 west	Eastern terminus of AR 322
		22.7	36.5	AR 14 (Jackson Street) – Newport, Marked Tree, Trumann
	​	28.7	46.2	AR 158 east	Western terminus of AR 158
Craighead	Jonesboro	37.7	60.7	AR 1B north / AR 163 south (Harrisburg Road) to AR 69	Southern terminus of AR 1B; northern terminus of AR 163
		38.0	61.2	AR 163S south (Apt Drive)	Northern terminus of AR 163S
		40.1	64.5	I-555 / US 49 south – Hoxie, Memphis	South end of US 49 overlap; exit 42 on I-555
See US 49 (mile 128.40–182.33)
Clay	Piggott			US 62 west – Corning, Piggott Business District US 49 ends	Northern terminus of US 49; south end of US 62 overlap
	​			AR 139 south – Holly Island	Northern terminus of AR 139
	​	0.0	0.0	US 62 east – St. Francis, Sikeston, MO	North end of US 62 overlap
	​	5.0	8.0	Route BB east to Route B – Holcomb	Continuation into Missouri
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus

Highway 1 has six business routes and one spur route. As cities have grown, bypasses have become necessary, and the former downtown alignments of Highway 1 have become the business routes discussed here. The St. Charles spur route terminates at the site of the Civil War Battle of Saint Charles upon the White River. The Forrest City business route intersects major routes US 70 and I-40. DeWitt, Marianna, Vanndale, and Cherry Valley all have business routes of less than 3.0 miles (4.8 km). The Jonesboro business route is the longest, and has an interchange with I-555.

A former Paragould connector route, Highway 1Y, was created in 1968 and now carries a designation of US 49Y.

• List of state highways in Arkansas
• List of highways numbered 1

• Media related to Arkansas Highway 1 at Wikimedia Commons