The arrondissement of Cayenne is an arrondissement of France in the French Guiana department in French Guiana region. It has 10 communes (since October 2022). Its population is 181,520 (2020), and its area is 17,029 km (6,575 sq mi) (since October 2022). It is the smallest of the three arrondissements in French Guiana, but also its most populated.

The communes of the arrondissement of Cayenne, and their INSEE codes, are:

The arrondissement of Cayenne, containing the coastal strip of French Guiana, was established in 1947. In 1969 the arrondissement of Inini, which covered the inland territory of French Guiana, was disbanded, and the territory of French Guiana was divided between the arrondissement of Cayenne and the new arrondissement of Saint-Laurent-du-Maroni.

Before 2015, the arrondissements of French Guiana were subdivided into cantons. The cantons of the arrondissement of Cayenne were, as of January 2015:

A government decree of October 26, 2022 detached the four communes of Saint-Georges, Camopi, Ouanary, and Régina from the arrondissement of Cayenne to form the new arrondissement of Saint-Georges.