Asaminami-ku (安佐南区) is one of the eight wards of the city of Hiroshima, located in the south of former Asa District [ja].

Asa District consisted of Gion-cho [ja], Yasufuruichi-cho [ja], Sato-cho [ja], Numata-cho [ja]. After being merged with Hiroshima in 1973, this ward was named Asaminami-ku. The largest station of Astramline, a new traffic system, is in Asaminami-ku. This system brought population inflow.

As of January 1, 2018, the ward has an estimated population of 245,475, with 101,941 households and a density of 2094 persons per km. The total area is 117.24 km.

• San'yō Expressway
  • Hiroshima IC [ja]
  • Numata PA [ja]
  • Hiroshima JCT [ja]
• Hiroshima Expressway (West Nippon Expressway Company)
  • Hiroshimaseifushinto IC [ja]
• Hiroshima Expressway
  • Numata IC [ja]

Hiroshima Mitsubishi Heavy Industries in Gion closed its doors in 2003.

• Hiroshima City University
• Hiroshima University of Economics
• Hiroshima Shudo University
• Yasuda Women's University

Former Sato-cho [ja], now a part of the ward, has been a major production area for Hiroshimana [ja] since Meiji era. Hiroshimana is a variety of Chinese cabbage and is the main material used for making Hiroshimanazuke (literally "pickled Hiroshimana").

In August 2014 many people died in a landslide after very heavy rain.