Asshole or arsehole is a vulgar term for the anus, or an insult derived from this meaning.

Asshole may also refer to:

• Asshole (album), by Gene Simmons
  • "Asshole", a song by Gene Simmons from his album, Asshole
• "Asshole" (song), by Denis Leary
• "Asshole", a song by Eminem from his album, The Marshall Mathers LP 2
• "Asshole", a song by Ronnie Radke from his mixtape, Watch Me
• Asshole (EP), an EP by Sebadoh
• Assholes: A Theory, a 2012 non-fiction book by Aaron James
  • Assholes: A Theory, a 2019 film directed by John Walker based on the book by Aaron James
• Asshole (card game)

• All pages with titles containing asshole
• Arsole, arsenic-containing chemical compound