Flora station is a historic Baltimore & Ohio Railroad depot which served Flora, Illinois. The depot was built from 1916 to 1917 by Frank Nichols; its design features several architectural styles, including Italian Renaissance Revival, Romanesque Revival, and Classical Revival. After the depot opened, the B&O Railroad became the largest employer in Flora, employing approximately half of the town's population through the mid-1920s, and was credited with the town's growth and economic success. The B&O also sponsored community groups such as a band and baseball teams. Passenger service to the station ended in 1973, and the empty station is now surrounded by vacant lots. The depot was added to the National Register of Historic Places on February 20, 1998, as the Baltimore and Ohio Railroad Depot.

Preceding station	Baltimore and Ohio Railroad			Following station
Kenner's toward St. Louis		St. Louis Line		Clay City toward Cumberland
Louis toward Beardstown		Beardstown – Shawneetown		Rinard toward Shawneetown