Barnwell House, also known as Prospect Hill Plantation, is a historic home located at Adams Run, Charleston County, South Carolina. It consists of the front or main portion dating from 1878 and the rear section from early to mid-19th century. The main part is a 2+1⁄2-story building, with a stuccoed brick first story and weatherboarded upper story. The front façade features a one-story portico with a bell cast hip roof supported by two solid Doric order fluted columns. It was listed on the National Register of Historic Places in 1980.