In spite of the written covenants on the holy scripture, Mian Abdul Nabi Kalhora got the two Talpur chiefs, Mir Abdullah Khan and Mir Fateh Khan, murdered in cold blood. This incident occurred in the year AH 1196/1782-83 CE. Some sources reveal that the Talpur chiefs were murdered while reciting the holy Quran, and this brought about general indignation and discontentment among the Baloch tribes of Sindh. Mir Fateh Ali son of Mir Sobdar and the grandson of Mir Bahram Khan, became the next leader of the Talpur confederacy and declared that he would punish Abdul Nabi Kalhora.
The Talpur confederacy, which was headed by Mir Fateh Ali, was aided by Mir Sohrab (of Khairpur) and Mir Tharo Manikani. The Baloch tribes were however divided in their affiliation. The Leghari, Nizamani, Marri, Jamali, Khatiyan, Khokhar and the Khaskheli tribes threw their lot with the Talpurs, whilst the Khosaa, Jatois, Numerias, Junejas, Lekheys, Kaleris, and the Khuhawars sided with the Kalhoras.
Battle
The Kalhora dynasty of Nawabs were supported by the Durrani Empire. While the Talpurs traced their roots back to Nader Shah had Qajar and possibly slight nominal support from the Mughal Empire.
At the Battle of Halani both sides ferociously deployed the usage of gunpowder weaponry. The battle was described by a future chronicler with one word Atishfishan (meaning "blazing flame"), this battle was even fought between gunboats in the Indus river.
The Talpurs emerged victorious, marking the end of Kalhora rule.
^Belkacem Belmekki, Michel Naumann (2022). Paradoxes of Pakistan: A Glimpse. Columbia University Press. p. 28. ISBN9783838216034. ..A very exacting Nawab provoked a revolt led by the Talpurs, Sindhi speaking Balochi people backed by the Mughals and the Persians. The Talpurs won the battle of Halani..
