Berchem-Sainte-Agathe (French, pronounced [bɛʁkɛm sɛ̃t aɡat]) or Sint-Agatha-Berchem (Dutch, pronounced [sɪnt aːˈɣaːtaː ˈbɛrxɛm] ), often simply called Berchem, is one of the 19 municipalities of the Brussels-Capital Region, Belgium. Located in the north-western part of the region, it is bordered by Ganshoren, Koekelberg, and Molenbeek-Saint-Jean, as well as the Flemish municipalities of Asse and Dilbeek. In common with all of Brussels' municipalities, it is legally bilingual (French–Dutch).

As of 1 January 2024, the municipality had a population of 25,787 inhabitants. The total area is 2.95 km (1.14 sq mi), which gives a population density of 8,741/km (22,640/sq mi). The municipality is known for its calm and peaceful character. It is said that Berchem is a "village in the city".

In the Middle Ages, Berchem-Sainte-Agathe was a modest village on the edge of Brussels. In 1795, it received the status of an autonomous municipality. In 1841, it separated from neighbouring Koekelberg, and in 1954, it became a part of the Brussels-Capital Region.

Berchem-Sainte-Agathe has a rich cultural and architectural heritage. Some of the main points of interest include:

• The former Church of St. Agatha, an old 12th-century Romanesque church. Completely renovated from 1972 to 1974, it is now deconsecrated and used for cultural ceremonies and celebrations.
• The Villa Marie-Mirande, an Art Nouveau house by the architect Victor Tinant.
• The Cité Moderne, a housing project designed and built from 1922 to 1924 by the modernist architect Victor Bourgeois.

• 
  Former Church of St. Agatha
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  Villa Marie-Mirande (1912)
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  Cité Moderne (1924)

• David Lachterman (1934–1992), radio and television comedian and commentary expert
• Alexis Saelemaekers (born 1999), football player who has played as a winger for R.S.C. Anderlecht and A.C. Milan
• Françoise Schepmans (born 1960), politician and mayor of Molenbeek, was born there.
• Jean-Claude Van Damme (born 1960), actor and martial artist, was born there.
• Rudi Vervoort (born 1958), politician and Minister-President of the Brussels-Capital Region, was born there.

• Media related to Berchem-Sainte-Agathe at Wikimedia Commons