Big Cove Tannery is an unincorporated community in Fulton County, Pennsylvania, United States. The community is located along Pennsylvania Route 928, 6.4 miles (10.3 km) south-southwest of McConnellsburg.

In 2017, the Pennsylvania Fish and Boat Commission announced that a part of Big Cove Creek near Big Cove Tannery in Fulton County, had been selected as one of 14 Keystone Select Stocked Trout Waters to be stocked with 14- to 20-inch trout.