Brome-Missisquoi (French pronunciation: [bʁɔm misiskwa]) is a regional county municipality in the Estrie region of Quebec, Canada. It lies in the Eastern Townships area. The seat is Cowansville. In 2021, it was transferred to the Estrie region from Montérégie.

In Parliament it is covered by the Brome—Missisquoi federal electoral district.

In the 1980s, the RCM was formed from municipalities of historic Brome and Missisquoi counties. On January 1, 2010, the city of Bromont moved from La Haute-Yamaska Regional County Municipality to Brome-Missisquoi.

There are 21 subdivisions within the RCM:

1 2 3 4 5 6 7 8 9 10 11 12 13 14 15 16 17 18 19 20 21

Name Votes Population Area (km^2) Abercorn 1 341 26.72 Bedford (Town) 1 2,558 4.23 Bedford (Township) 1 658 31.96 Bolton-Ouest 1 732 100.94 Brigham 1 2,282 86.92 Brome 1 341 11.56 Bromont 6 11,357 114.05 Cowansville 8 15,234 46.87 Dunham 2 3,599 193.86 East-Farnham 1 612 5.02 Farnham 5 10,149 92.12 Frelighsburg 1 1,123 123.31 Lac-Brome 3 5,923 206.9 Notre-Dame-de-Stanbridge 1 691 43.89 Pike-River 1 503 40.77 Saint-Armand 1 1,228 83.16 Sainte-Sabine 1 1,105 55.33 Saint-Ignace-de-Stanbridge 1 677 69.42 Stanbridge East 1 834 49.41 Stanbridge Station 1 291 18.07 Sutton 2 4,548 245.69 Total 41 64,786 1650.20

Historical census data - Brome-Missisquoi Regional County Municipality, Quebec

Year Pop. ±% 1991 45,257 —     1996 45,987 +1.6% 2001 46,165 +0.4%	Year Pop. ±% 2006 46,720 +1.2% 2010A 52,769 +12.9% 2011 55,621 +5.4%	Year Pop. ±% 2016 58,314 +4.8% 2021 64,786 +11.1%
, 2021 (A) adjustment due to boundary change.

Canada Census mother tongue - Brome-Missisquoi Regional County Municipality, Quebec
Census		Total		French				English				French & English				Other
Year		Responses		Count	Trend	Pop %		Count	Trend	Pop %		Count	Trend	Pop %		Count	Trend	Pop %
2021		63,560		50,310	12.2%	79.04%		9,885	0.97%	15.55%		1,585	82.18%	2.49%		1,490	12.03%	2.34%
2016		56,955		44,820	71.2%	78.69%		9,790	4.4%	17.02%		870	3.57%	1.53%		1,330	5.5%	2.33%
2011		54,590		42,240	25.9%	77.38%		10,250	4.2%	18.78%		840	18.3%	1.54%		1,260	2.7%	2.31%
2006		45,400		33,560	1.8%	73.92%		9,835	2.8%	21.66%		710	4.7%	1.56%		1,295	30.8%	2.85%
2001		44,830		32,975	2.7%	73.56%		10,120	6.1%	22.57%		745	4.9%	1.66%		990	11.2%	2.21%
1996		44,485		32,105	n/a	72.17%		10,780	n/a	24.23%		710	n/a	1.60%		890	n/a	2.00%

Highways and numbered routes that run through the municipality, including external routes that start or finish at the county border:

• List of regional county municipalities and equivalent territories in Quebec

• Official site
• Official MRC site
• Tourism website of Brome-Missisquoi
• Cultural website of Brome-Missisquoi
• The Wine Route of Brome-Missisquoi
• Statistics Canada Archived 2008-10-13 at the Wayback Machine