Burgandine House is a historic home located at Culpeper, Culpeper County, Virginia. It was built about 1700, and is a 1+1⁄2-story, plank log dwelling. It has a gable roof and weatherboard siding. The building served periodically for several years as the headquarters for the Culpeper Historical Society. It is considered the oldest residence in Culpeper.

It was listed on the National Register of Historic Places in 1997.