Cabell Midland High School is located in Ona, West Virginia. Cabell Midland is a four-year high school which serves grades 9 through 12. The school's name is derived from two sources; "Cabell" for the county in which it is located, and "Midland" for the famous Midland Trail which once extended from Norfolk, Virginia to Los Angeles, California.

The school serves students predominantly from the eastern part of Cabell County from Barboursville Middle School and Milton Middle School. The building was constructed in 1994 through of the consolidation of Barboursville High School and Milton High School. The approximately 286,000-square-foot (26,600 m) building was designed by the Charleston, West Virginia architectural firm of Williamson Shriver Architects. The design received an Honor Award for Architectural Excellence from the West Virginia Chapter of the American Institute of Architects (AIA-WV) in 1995. The temporary name of the school during the planning stages was Cabell East High School, but after asking for input and ideas from the public, the official name of Cabell Midland High School was later decided on by the Cabell County Board Of Education. The name of the other public high school in Cabell County, Huntington High School (which combined "Old" Huntington High School and Huntington East High School), went through the same process, originally being called Cabell West High School, then Huntington Summit High School, and finally Huntington High School.

Cabell Midland, with an enrollment of 1,834 as of 2012, was and is the largest student body in the state and among the largest 15% of schools in the country. The population was 51% male; 97.8% White, 0.8% Black, 0.8% Asian, 0.4% Hispanic, and 0.2% American Indian. The student-to-teacher ratio was 17.9, ranking 116th of the 159 secondary schools in the state. As of the 2018-2019 school year, Cabell Midland has 1,857 students and a faculty of 195 employees.

CMHS is a member of the Mountain State Athletic Conference (MSAC) and competes in the state's "large school" division of AAAA.

Listed below are all championships won by Milton High School (M) and Barboursville High School (B).

	State championships	State runners-up
Sport	Year(s)	Year(s)
Boys basketball	1975 (B)	1961 (M)
Football	1953 (B)	1949 (M), 1954 (B), 1983 (B), 1984 (B)
Golf	1965 (B), 1966 (B), 1983 (B), 1984 (B), 1985 (B)	1964 (B), 1980 (B), 1993 (B)
Softball	1987 (M), 1990 (M), 1991 (M)
Girls track	1980 (M), 1981 (M)

Listed below are all championships won by Cabell Midland High School after the year 1994.

	State championships	State runners-up
Sport	Year(s)	Year(s)
Baseball	2003, 2023, 2024	2006, 2013
Boys basketball	2002
Girls basketball		2021
Cheer		2001
Boys cross country	1996, 2000, 2001, 2004, 2009, 2010, 2012, 2015, 2018	1999, 2003, 2005, 2007, 2011, 2013, 2014, 2016
Girls cross country		1994, 1997, 2018
Football		2012, 2019
Golf	2000, 2015, 2016, 2017	2004, 2013, 2021, 2022
Boys soccer		2019
Girls soccer	2017
Softball	1995, 1997, 1999, 2000, 2005, 2021
Girls tennis	2000
Boys track	1996, 1997, 1998, 1999, 2003, 2004, 2005, 2008, 2016, 2024
Girls track	2006
Volleyball	1995	1995, 1997, 2018

Cabell Midland's mascot is the Scarlet Knight, which was chosen via a poll of the students of Milton and Barboursville high schools in 1993, the two that consolidated to form Cabell Midland. The school colors are scarlet and silver.

• Katie Lee: food critic, chef; third wife of Billy Joel
• Jason Starkey: NFL player