Kayseri (Turkish pronunciation: [ˈkajseɾi]) is a large city in Central Anatolia, Turkey, and the capital of Kayseri province. Historically known as Caesarea, it has been the historical capital of Cappadocia since ancient times. The Kayseri Metropolitan Municipality area is composed of five districts: the two central districts of Kocasinan and Melikgazi, and since 2004, also outlying Hacılar, İncesu, and Talas.

As of 31 December 2021, the province had a population of 1,434,357 of whom 1,175,886 live in the four urban districts, excluding İncesu which is not conurbated (i.e. not contiguous, having a largely non-protected buffer zone).

Kayseri sits at the foot of Mount Erciyes (Turkish: Erciyes Dağı), a dormant volcano that reaches an altitude of 3,916 metres (12,848 feet), more than 1,500 metres above the city's mean altitude. It contains a number of historic monuments, particularly from the Seljuk period. Tourists often pass through Kayseri en route to the attractions of Cappadocia to the west.

Kayseri is served by Erkilet International Airport and is home to Erciyes University.

Kayseri was originally called Mazaka or Mazaca (Armenian: Մաժաք, romanized: Mažak'; according to Armenian tradition, it was founded by and named after Mishak) and was known as such to the geographer Strabo, during whose time it was the capital of the Roman province of Cappadocia, known also as Eusebia at the Argaeus (Εὐσέβεια ἡ πρὸς τῷ Ἀργαίῳ in Greek), after Ariarathes V Eusebes, King of Cappadocia (163–130 BC).

In 14 AD its name was changed by Archelaus (d. 17 AD), the last King of Cappadocia (36 BC–14 AD) and a Roman vassal, to "Caesarea in Cappadocia" (to distinguish it from other cities with the name Caesarea in the Roman Empire) in honour of Caesar Augustus upon his death. This name was rendered as Καισάρεια (Kaisáreia) in Koine Greek, the dialect of the later Byzantine (Eastern Roman) Empire, and it remained in use by the natives (nowadays known as Cappadocian Greeks, due to their spoken language, but then referred to as Rum due to their previous Roman citizenship) until their expulsion from Turkey in 1924. (Note that letter C in classical Latin was pronounced K. When the first Turks arrived in the region in 1080 AD, they adapted this pronunciation, which eventually became Kayseri in Turkish, remaining as such ever since.)

Kayseri experienced three golden ages. The first, dating to 2000 BC, was when the city formed a trade post between the Assyrians and the Hittites. The second came under Roman rule (1st to 11th centuries). The third golden age was during the reign of the Seljuks (1178–1243), when the city was the second capital of the Seljuk Sultanate of Rum. The relatively short Seljuk period left a large number of historic landmarks including the Hunat Hatun Complex, the Kiliç Arslan Mosque, the Ulu Camii (Grand Mosque) and the Gevher Nesibe Hastanesi (Hospital).

As Mazaca (Ancient Greek: Μάζακα), the city served as the residence of the kings of Cappadocia. In ancient times, it was on the crossroads of the trade routes from Sinope to the Euphrates and from the Persian Royal Road that extended from Sardis to Susa during the 200+ years of Achaemenid Persian rule. In Roman times, a similar route from Ephesus to the East also crossed the city.

Basil of Caesarea, one of the Cappadocian Fathers, established a large monastic complex, the Basileiad, in Caesarea Mazaca in the 4th century. Nothing remains of it today.

The city stood on a low spur on the north side of Mount Erciyes (Mount Argaeus in ancient times). Very few traces of the ancient site now survive. For more on the Roman and Byzantine eras see Caesarea (Mazaca).

The Arab general (and later the first Umayyad Caliph) Muawiyah invaded Cappadocia and took Caesarea from the Byzantines temporarily in 647. The city was called Kaisariyah (قيصرية) by the Arabs, and later Kayseri (قیصری) by the Seljuk Turks after it was captured by Alp Arslan in 1067. Alp Arslan's forces demolished the city and massacred its population. The shrine of Saint Basil was also sacked after the fall of the city. As a result, the city remained uninhabited for the next half century.

From 1074 to 1178 the area was under the control of the Danishmendids who rebuilt the city in 1134. The Anatolian Seljuk Sultanate controlled the city from 1178 to 1243 and it was one of their most important centres until it fell to the Mongols in 1243. Within the walls lies the greater part of Kayseri, rebuilt between the 13th and 16th centuries. The city then fell to the Eretnids before finally becoming Ottoman in 1515. It was the centre of a sanjak called initially the Rum Eyalet (1515–1521) and then the Angora vilayet (founded as Bozok Eyalet, 1839–1923).

The Grand Bazaar dates from the latter part of the 1800s, but the adjacent caravanserai (where merchant traders gathered before forming a caravan) dates from around 1500. The town's older districts (which were filled with ornate mansion-houses mostly dating from the 18th and 19th centuries) were subjected to wholesale demolition starting in the 1970s.

The building that hosted the Kayseri Lyceum was rearranged to host the Turkish Grand National Assembly during the Turkish War of Independence when the Greek army was advancing on Ankara, the base of the Turkish National Movement.

Kayseri has a continental climate (Köppen: Dsa, Trewartha: Dc). It experiences cold, snowy winters and hot, dry summers with cool nights. Precipitation occurs throughout the year, albeit with a marked decrease in late summer and early fall.

The city of Kayseri consists of sixteen metropolitan districts: Akkışla, Bünyan, Develi, Felâhiye, Hacılar, İncesu, Kocasinan, Melikgâzi, Özvatan, Pınarbaşı, Sarıoğlan, Sarız, Talas, Tomarza, Yahyâlı, and Yeşilhisar.

Kayseri features a range of historical and cultural attractions that reflect the city’s heritage. Republic Square is a central public space in Kayseri, surrounded by notable buildings. Inside the centre of Kayseri the most unmissable reminder of the past are the huge basalt walls that once enclosed the old city. Dating back to the sixth century and the reign of the Emperor Justinian, they have been repeatedly repaired, by the Seljuks, by the Ottomans and more recently by the current Turkish government. In 2019 Kayseri Archaeology Museum moved from an outlying location to a new site inside the walls. Kayseri Clock Tower, built in the early 20th century by Abdülhamid II, is located in the city center and remains a recognizable landmark. Bürüngüz Mosque, constructed in the 13th century, is an example of Seljuk architecture and is still in use today.

Surp Asdvadzadzin Virgin Mary Church Research Library, located within the Surp Asdvadzadzin Church. The Atatürk House Museum is located in a house where Mustafa Kemal Atatürk stayed, providing historical context about the early years of the Turkish Republic. The National Struggle Museum focuses on the history of the Turkish War of Independence and the role of Kayseri in the formation of the modern Turkish state.

The Grand Mosque (Turkish: Ulu Cami) was started by the Danişmend emir Melik Mehmed Gazi who is buried beside it although it was only completed by the Seljuks after his death. There are many magnificent reminders of the Seljuk supremacy in and around the walls as well as many much smaller kümbets (domed tombs) of which the most impressive is the Döner Kümbet (lit. Revolving Tomb). The oldest surviving Seljuk place of worship – and the oldest Seljuk mosque built in Turkey – is the Hunat Hatun Mosque Complex which still includes a functioning hamam with separate sections for men and women dating back to 1238.

Near the mosque is the Sahabiye Medresesi, a theological school dating back to 1267 with a magnificent portal typical of Seljuk architecture. Very similar is the Avgunlu Medresesi which now serves as a large bookshop-cum-cafe in a park. In Mimar Sinan Park stands the Çifte Medresesi, a pair of Seljuk-era theological schools that eventually served as a hospital for those with psychiatric disorders. They were commissioned by the Seljuk sultan Giyasettin I Keyhüsrev and his sister, Gevher Nesibe Sultan, who is buried inside. Today the buildings house the Museum of Seljuk Civilisations.

Another Seljuk survivor is the grand Halikılıç Mosque complex which has two spectacular entrance portals. It dates back to 1249 but was extensively restored three centuries later. Post-dating the Seljuks is the Güpgüpoğlu Mansion which dates back to the early 15th century but is open to the public with the furnishings it would have had in the late 19th century when it was home to the poet and politician Ahmed Midhad Güpgüpoğlu.

Close to the walls is Kayseri's own Kapalı Çarşı (Turkish: Kapalı Çarşı), still a bustling commercial centre selling cheap clothes, shoes and much else. Deep inside it is the older and very atmospheric Vezir Han which was commissioned in the early 18th century by Nevşehir-born Damad İbrahim Paşa who became a grand vizier to Sultan Ahmed III before being assassinated in 1730.

The Kayseri suburb of Talas was the ancestral home of Calouste Gulbenkian, Aristotle Onassis and Elia Kazan. Once ruinous following the expulsion of its Armenian population in 1915 and then of its Greek population in 1923, it was largely reconstructed in the early 21st century. The Greek Orthodox Church of Saint Mary, built in 1888, has been converted into the Yaman Dede Mosque. Similarly attractive is the suburb of Germir, home to three 19th-century churches and many fine old stone houses.

Mount Erciyes (Turkish: Erciyes Dağı) looms over Kayseri and serves as a trekking and alpinism centre. During the 2010s an erstwhile small, local ski resort was developed into more of an international attraction with big-name hotels and facilities suitable for all sorts of winter pastimes.

The archaeological site of Kanesh-Kültepe, one of the oldest cities in Asia Minor, is 20 km northeast of Kayseri.

Ağırnas, a small town with many lovely old houses, was the birthplace in 1490 of the great Ottoman architect Mimar Sinan, and a house traditionally associated with him is open to the public as a museum. Beneath it there is one of the 'underground cities' so typical of Cappadocia. The restored Church of Saint Procopius dates back to 1857 and serves as a cultural centre.

The small town of Develi also contains some attractive old houses. The 19th-century Armenian Church of Saint Mary has been turned into the Lower Everek Mosque (Turkish: Aşağı Everek Cami).