Cairo Regional Airport, (IATA: CIR, ICAO: KCIR, FAA LID: CIR) is a county-owned public-use airport located 4 nautical miles (7.4 km; 4.6 mi) northwest of the central business district of Cairo, Illinois, a city in Alexander County, Illinois, United States. It is included in the Federal Aviation Administration (FAA) National Plan of Integrated Airport Systems for 2019–2023, in which it is categorized as a local general aviation facility.

The two closest airports with commercial airline service are Cape Girardeau Regional Airport and Barkley Regional Airport which are both about 23 miles (37 km) away.

Cairo Regional Airport covers an area of 470 acres (190.2 ha) at an elevation of 322 feet (98 m) above mean sea level. It has two runways: 14/32 is 4,001 by 100 feet (1,220 x 30 m) with an asphalt surface and 2/20 is 3,200 by 60 feet (975 x 16 m) with an asphalt surface.

The airport operates its own fixed-base operator on the field. The FBO offers fuel as well as a cafe, a lounge, rest rooms, flight planning stations, and refreshments.

For the 12-month period ending September 30, 2020, the airport had 9,000 aircraft operations, an average of 25 per day: 94% general aviation and 6% military. For the same time period, there were 12 airplanes based at this airport: 11 single engine and 1 multi engine.

• List of airports in Illinois

• FAA Terminal Procedures for CIR, effective December 26, 2024
• Resources for this airport:
  • FAA airport information for CIR
  • AirNav airport information for CIR
  • FlightAware airport information and live flight tracker
  • SkyVector aeronautical chart for CIR