Calais Middle/High School (Calais or CMHS) is a public middle school and high school in Calais, Maine. The high school is located in Calais Education Park, near Washington County Community College and the St. Croix Regional Technical Center.

CMHS has various varsity sports teams, including Baseball, Basketball, Cheering, Cross country, Golf, Soccer, Softball, Tennis, Track and field, Volleyball, and Wrestling.

CMHS has several extracurriculars, including Student Council, Drama, Yearbook Committee, a Civil Rights Team, United States Academic Decathlon, Skills USA, Skatepark Committee, School Climate Committee, Jobs For Maine's Graduates, Band, Jazz Band, Chorus, National Honor Society, and a Math Team.

• Lyn Mikel Brown, academic, author, and activist
• Vinton Cassidy, politician
• George M. Hanson, judge
• Harold H. Murchie, judge and politician

• Franklin W. Johnson, 15th president of Colby College and former principal