Calderara di Reno (Bolognese: Caldarèra) is a comune (municipality) in the Metropolitan City of Bologna in the Italian region Emilia-Romagna, located about 10 kilometres (6 mi) northwest of Bologna.

The frazione of Sacerno is usually considered the place where, in 43 BC, Octavian, Mark Antony and Lepidus met to set the Second Triumvirate.