Calhoun-Isles is one of the official communities (a grouping of several official neighborhoods) in the U.S. city of Minneapolis. It is split between Ward 7 and Ward 10 of the Minneapolis City Council, represented by councilmembers Katie Cashman and Aisha Chughtai, respectively.

It contains the Uptown business district and the name "Uptown" is frequently (though somewhat incorrectly) used to refer to the entire community. The name of the community refers to its most prominent physical features, the large and publicly accessible lakes Bde Maka Ska (formerly known as "Lake Calhoun") and Lake of the Isles.

Calhoun-Isles is an affluent part of the city, and people of upper middle class means and above, including young professionals and older millionaires, inhabit the community. The Uptown district is known for its entertainment and nightlife.

Neighborhoods of Calhoun-Isles

• Bryn Mawr
• Cedar-Isles-Dean
• East Bde Maka Ska
• East Isles
• Kenwood
• Lowry Hill
• Lowry Hill East
• South Uptown
• West Maka Ska

44°57′41″N 93°18′35″W / 44.9613°N 93.3097°W / 44.9613; -93.3097