State Route 120 (SR 120) is a state highway in the central part of California, connecting the San Joaquin Valley with the Sierra Nevada, Yosemite National Park, and the Mono Lake area. Its western terminus is at Interstate 5 in Lathrop, and its eastern terminus is at U.S. Route 6 in Benton. While the route is signed as a contiguous route through Yosemite, the portion inside the park is federally maintained and is not included in the state route logs. The portion at Tioga Pass at Yosemite's eastern boundary is the highest paved through road in the California State Route system. This part is not maintained in the winter and is usually closed during the winter season.

SR 120 begins as a freeway intersecting Interstate 5 to extend Interstate 205 through Manteca. In east Manteca the freeway ends at SR 99 and becomes a highway which continues to head east through Escalon, Oakdale and other various small towns. East of Oakdale there are no highly populated areas for 90 miles (144 km) as it heads into the foothills of the Sierra Nevada and into Yosemite National Park. Entering Yosemite, SR 120 is known as Big Oak Flat Road as it heads towards Crane Flat. After leaving Crane Flat, Big Oak Flat Road turns southeast towards Yosemite Valley, while SR 120 continues east as Tioga Pass Road (or often simply Tioga Road). The highway retains that name as it travels through Tuolumne Meadows, over Tioga Pass at an elevation of 9,945 feet, and through the Lee Vining Canyon on its 59-mile (95 km) journey to its intersection with U.S. Route 395, at Lee Vining. After a jog to the south along US 395, it continues east as Mono Mills Road, skirting the south end of Mono Lake and providing access to the Mono Lake South Tufa as well as the historical site of Mono Mills before cresting Sagehen Summit and ending with the intersection of U.S. Route 6 at Benton. Both the portions through Yosemite National Park and the stretch between Mono Lake and Benton are subject to winter closure. Usually the highway is open through Tioga Pass by the Memorial Day weekend at the end of May, and typically closes for the winter sometime in November.

Tioga Road/Big Oak Flat Road is officially both a National Scenic Byway and a National Forest Scenic Byway. The segment through the Lee Vining Canyon between the eastern edge of Yosemite and US 395 is designated as the Lee Vining Canyon Scenic Byway, a separate National Forest Scenic Byway.

SR 120 is part of the California Freeway and Expressway System, and both the western portion and the eastern portion west of US 395 are part of the National Highway System, a network of highways that are considered essential to the country's economy, defense, and mobility by the Federal Highway Administration. SR 120 is eligible to be included in the State Scenic Highway System, but it is not officially designated as a scenic highway by the California Department of Transportation. The Tioga Pass Road was designated as a California Historic Civil Engineering Landmark by the American Society of Civil Engineers in 2002.

During the Gold Rush, SR 120 was originally known as Big Oak Flat Road, after the village of Big Oak Flat through which it passes in the Sierra foothills. It was a pack trail from Stockton which became popular with prospectors about 1849. By 1874 it was a wagon road which extended to Yosemite Valley.

In 1921, the California State Assembly authorized San Joaquin County to transfer the county road connecting Manteca with then-Route 5 (now I-5) at Mossdale to the state. It was numbered Route 66, as was a 1933 extension from Manteca east to Route 13 in Oakdale. Also in 1933, Route 40 was extended east from Mono Lake to Route 76 (US 6) at Benton. The route from Manteca to Benton was marked as Sign Route 120 in 1934, and was soon extended west to Mossdale, replacing what had been part of U.S. Route 99W.

West of Priest is a section of highway with over one hundred curves and hairpin turns, known as the "New Priest Grade." With a 4% grade, it opened in 1915 and was built by a group of local volunteers who desired an alternative to the very steep (17%) Old Priest Grade. Today, both grades are paved, but trailers and RVs are prohibited from Old Priest Grade. There is a 7,500-pound weight limit on the old grade.

In 1956, National Park Service developed plans to relocate the Big Oak Flat Road from Crane Flat to the park's eastern boundary, and reconstruct the unimproved central section of the Tioga Road. NPS management wanted to "open up" the High Sierra section of the park to vastly increased numbers of visitors, and planned a new visitor center and other facilities at Tuolumne Meadows, as well as campgrounds and other facilities along the Tioga Road. This brought fierce opposition from the Sierra Club, led by famed photographer Ansel Adams. Adams and his supporters opposed the blasting of a great granite dome southwest of Tenaya Lake, as well as routing the highway along the western shore of the lake. Internally, however, many Sierra Club members supported the project. At the time, Sierra Club opposition created a serious rift in the long-time close relationship between the environmental organization and the National Park Service. In the end, the government proceeded to build the project as originally planned, with only minor modifications.

On November 25, 2020, the first diverging diamond interchange in the state of California opened to traffic at the interchange with Union Road (exit 4) in Manteca.

Except where prefixed with a letter, postmiles were measured on the road as it was in 1964, based on the alignment that existed at the time, and do not necessarily reflect current mileage. R reflects a realignment in the route since then, M indicates a second realignment, L refers to an overlap due to a correction or change, and T indicates postmiles classified as temporary (for a full list of prefixes, see California postmile § Official postmile definitions). Segments that remain unconstructed or have been relinquished to local control may be omitted. The numbers reset at county lines; the start and end postmiles in each county are given in the county column.

County	Location	Postmile	Exit	Destinations	Notes
San Joaquin SJ R0.49-21.18	Lathrop	R0.49	1	I-5 – San Francisco, Los Angeles, Stockton, Sacramento	Westbound exit and eastbound entrance; signed as exits 1A (south) and 1B (north); west end of SR 120; former US 50 west; I-5 exit 461
	Manteca	R1.33	1C	Yosemite Avenue	Signed as exit 1 eastbound
		​	2	McKinley Avenue	Interchange under construction
		R3.32	3	Airport Way (CR J3) – Sharpe Depot
		R4.31	4	Union Road	Diverging diamond interchange: first one constructed in California and opened to traffic on November 25, 2020
		R5.31	5	South Main Street
		T6.87 5.82	6	SR 99 south – Modesto, Fresno, Los Angeles	West end of SR 99 overlap; SR 99 exit 241
		6.65 6.20	East end of freeway on SR 99
				SR 99 north / Yosemite Avenue – Sacramento, Central Manteca	Interchange; east end of SR 99 overlap; SR 99 exit 242
		8.84		CR J5 (Jack Tone Road)
	​	11.64		French Camp Road
	Escalon	​		CR J6 / CR J7 north (Escalon-Bellota Road, McHenry Avenue) – Farmington, Modesto	West end of CR J7 overlap
		R16.92		CR J7 south (Main Street) / Kern Street	East end of CR J7 overlap
Stanislaus STA 0.00-T18.17	​	3.16		CR J9 north (Valley Home Road) – Valley Home	West end of CR J9 overlap
	​	​		CR J14 north (Twenty-Six Mile Road)	West end of CR J14 overlap
	Oakdale	5.12		SR 108 west (F Street) / CR J9 / CR J14 south (Yosemite Avenue) – Modesto	West end of SR 108 overlap; east end of CR J9 / CR J14 overlap
Tuolumne TUO R0.00-R41.52	​	8.19		CR J59 (La Grange Road) – La Grange, Merced	Northern terminus of CR J59
	​	​		CR E15 (O'Byrnes Ferry Road) – Copperopolis	Southern terminus of CR E15
	​	12.08		SR 108 east – Sonora	East end of SR 108 overlap
	Chinese Camp	15.52		SR 49 north – Sonora	West end of SR 49 overlap
	Tuolumne River / Don Pedro Reservoir	R19.61	James E. Roberts Bridge
	​	R23.90		SR 49 south – Coulterville, Mariposa	East end of SR 49 overlap
	Buck Meadows	R39.46		CR J132 (Smith Station Road, Greeley Hill Road) to SR 132 – Coulterville, Merced	Eastern terminus of CR J132
	Yosemite National Park		East end of state maintenance at western park boundary
		​	Big Oak Flat Entrance Station; park fee or pass required for entry
Mariposa MPA R41.52-43.75		​		Big Oak Flat Road to SR 41 / SR 140 – Yosemite Valley
		​	Tuolumne Grove (winter closure gate near the eastern end of the grove)
Tuolumne TUO 43.75-R56.15		​	Tioga Pass Entrance Station (closed in winters); park fee or pass required for entry
		​	West end of state maintenance at eastern park boundary
Mono MNO R0.00-58.99	​	R8.54	Westbound winter closure gate
	Lee Vining	R12.06 50.74		US 395 north / Airport Road – Reno	West end of US 395 overlap
	June Lake Loop North Junction	46.40		SR 158 south – June Lake	Northern terminus of SR 158
	Mono Mills Junction	45.96 13.37		US 395 south – Bishop	East end of US 395 overlap
	​	18.49	Eastbound winter closure gate
	​	39.05	Westbound winter closure gate
	​	51.86		Benton Crossing Road to US 395 – Owens River, Crowley Lake
	Benton	58.99		US 6 – Tonopah, Bishop	East end of SR 120
1.000 mi = 1.609 km; 1.000 km = 0.621 mi       Concurrency terminus        Tolled

• California Roads portal

• Map: "Stanislaus National Forest, California," U.S. Forest Service, 1979.

• Caltrans: State Route 120 highway conditions
• Caltrans Traffic Conditions Map
• California Highway Patrol Traffic Incidents
• A Brief History Of The Tioga Road
• Tioga Road (Highway 120 through the Yosemite National Park) conditions
• California @ AARoads.com - State Route 120
• California Highways: SR 120