The canton of La Grand-Croix is a French former administrative division located in the department of Loire and the Rhone-Alpes region. It was disbanded following the French canton reorganisation which came into effect in March 2015. It had 24,646 inhabitants (2012).

The canton comprised the following communes:

• Cantons of the Loire department

45°29′38″N 4°33′44″E / 45.4938°N 4.5623°E / 45.4938; 4.5623