Casa de Carrillo House in San Diego, California, in San Diego County, is a California Historical Landmark No. 74 listed on December 6, 1932. The Casa de Carrillo House is the oldest residence in San Diego. The Casa de Carrillo House was built by Presidio of San Diego Comandante Francisco María Ruiz (1754–1839). Ruiz was the leader of the Presidio from 1809 to 1827. The Casa de Carrillo house was built next to his pear orchard planted in 1808. The adobe house was used by his relative and soldier, Joaquín Carrillo, and his family. Joaquín Carrillo, daughter Josefa Carrillo, ran away and sailed from the home and eloped to Chile with Henry Delano Fitch in April 1829. Francisco Ruiz died in 1839, when Joaquín Carrillo died, his son Ramon Carrillo sold the house and land to Lorenzo Soto. The house and land was sold a few times, it was poor condiction when sold in 1932 to George Marston and associates. George Marston and associates restored the house. After the restoration George Marston and associates donated the house and land to the City of San Diego. The City of San Diego turned the house and land into the Presidio Hills Golf Course.

A California Historical marker is at the Old Town, San Diego, Presidio Hills Golf Course, NE of Juan Street on Wallace Street. The Marker was place there in 1994 by State Department of Parks and Recreation working with the San Diego City Department of Parks and Recreation and Squibob Chapter, E Clampus Vitus.

• California Historical Landmarks in San Diego County
• El Campo Santo
• Carrillo family of California
• María Ygnacia López de Carrillo