Cedar Grove Rural Crossroads Historic District is a national historic district located at Cedar Grove, Orange County, North Carolina. The district encompasses 44 contributing buildings, 9 contributing sites, and 7 contributing structures in the rural crossroads community of Cedar Grove. The district developed from the mid-19th to mid-20th century, and includes notable examples of Late Victorian and Colonial Revival style architecture. Notable buildings include the Rogers-McDade House, Eno Presbyterian Church (1897-1899), Cedar Grove Methodist Church (1939), Allison-Oliver-Pender Store (1880s), and Allen A. Ellis Store (1923).

It was listed on the National Register of Historic Places in 1998.