Centennial Collegiate Vocational Institute is a secondary high school located in ward five of Guelph, Ontario, Canada. Centennial offers many programs including science, math, business, English, French, and biotechnology. The school colours are purple and gold. Centennial has offered AP exams (advanced placement) for over 20 years.

The school is located in the North East side of the city of Guelph, Ontario, Canada. Centennial was opened in 1967, 100 years after Canadian Confederation, as indicated by its name and is operated by the Upper Grand District School Board. The high school was ranked 3rd of 719 in the Fraser Institute Report Card on Ontario Secondary School's 2007 Edition. As of 2023, Centennial is ranked 35th out of 739 high schools in Ontario in the Fraser report.

Some former Centennial students have gone on to become successful in their careers. One example of this is Victor Davis, who was a successful Canadian swimmer, and Olympic Medalist.

This article's list of alumni may not follow Wikipedia's verifiability policy. Please improve this article by removing names that do not have independent reliable sources showing they merit inclusion in this article AND are alumni, or by incorporating the relevant publications into the body of the article through appropriate citations. (March 2024)

• Thomas Dimitroff - General Manager of the Atlanta Falcons
• George McPhee - General Manager of the Vegas Golden Knights NHL franchise,
• David Gibbins - Novelist and archaeologist
• Victor Davis - Olympic swimmer/medalist
• Scott Diamond - Toronto Blue Jays pitcher

• Education in Ontario
• List of secondary schools in Ontario

• Centennial Collegiate Vocational Institute

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Related categories for Ontario:

• High (secondary) schools (related article)
• Middle (junior high) schools (related article)
• Elementary (primary) schools (related article)