Ü-Tsang (དབུས་གཙང་། Wylie; dbus gtsang) is one of the three Tibetan regions, the others being Amdo in the north-east, and Kham in the east. The region of Ngari in the north-west was incorporated into Ü-Tsang after the Tibet–Ladakh–Mughal War. Geographically Ü-Tsang covered the south-central part of the Tibetan cultural area, including the Brahmaputra River watershed. The western districts surrounding and extending past Mount Kailash are included in Ngari, and much of the vast Changtang plateau to the north. The Himalayas defined Ü-Tsang's southern border. The present Tibet Autonomous Region corresponds approximately to Ü-Tsang and the western part of Kham.

Ü-Tsang was formed by the merging of two earlier power centers: Ü (Wylie: dbus) in central Tibet, controlled by the Gelug lineage of Tibetan Buddhism under the early Dalai Lamas, and Tsang (Wylie: gtsang) which extended from Gyantse to points west, controlled by the rival Sakya lineage. Military victories by the powerful Khoshut Mongol Güshi Khan that backed 5th Dalai Lama and founded Ganden Phodrang government in 1642, consolidated power over the combined region. It was followed by the direct and indirect rule of the Qing Dynasty, which started in 1720 by the Qianlong Emperor and continued till the Chinese revolution of 1911. The retinue of the Panchen Lama was accused of using Tsang and Ü to "sow discord".

Ü-Tsang is the cultural heartland of the Tibetan people, originally governed by Rinpungpa dynasty. The Tsangpa dynasty had ruled the Tsang part between 1565 and 1642. The dispute between Tsang kings, Karma Tenkyong Wangpo followers of karmapa and Khoshut khans, Güshi Khan, follower of gelugpa and Dalai Lamas ended by the rule on Tibet from the Potala and Norbulingka palaces in Lhasa from the last one. Jokhang, a Tibetan Buddhist temple, is located there. The Lhasa dialect is used as a lingua franca in Ü-Tsang and the Tibetan Exile koiné language is also based largely on it.

30°51′21″N 92°13′38″E / 30.85583°N 92.22722°E / 30.85583; 92.22722