The Chapel Rural Historic District is an expansive rural historic district in Clarke County, Virginia. The district encompasses an area of nearly 11,500 acres (4,700 ha), a rural landscape that extends from Millwood in the south, nearly to Berryville in the north. The district takes its name from the Old Chapel, an 18th-century building that stands prominently at the junction of several roads near the center of the district. The district includes nearly 700 contributing properties.

The district was listed on the National Register of Historic Places in 2014.

• A few of the historic sites within this district:
• 
  Old Chapel and Cemetery
• 
  Salem Regular Baptist Church
• 
  Salem Regular Baptist Church Cemetery
• 
  Millwood Shiloh Baptist Church
• 
  Millwood United Methodist Church
• 
  Christ Church, Millwood
• 
  Old Schoolhouse, now Red Schoolhouse Antiques
• 
  Old Barn, now Black Penny Antiques